Defect of Sugar-coating tablet

1. Chipping of the tablet coating

• This is often caused by a low concentration or absence of polymer
• add more polymer to the coating solution.
• Another cause is the excessive use of pigments and insoluble fibres
• reduce the number of fillers

2. Cracking

• Expansion of the tablet during or after coating caused by stress relaxation or moisture absorption –
• consider the use of seal coat or extend the time between the sugar coating and compaction

3. Non-drying of the coating

• Excessive presence of invert sugar –
• avoid the excess heating of the sucrose syrup under acidic conditions

4. Twinning

• High edge walls/flat surface
• modify or alter the punch design

5. Uneven colouring

• Poor distribution of coating solution
• add sufficient liquid and ensure that it is fully mixed
• Colour migration due to under/rapid drying
• optimize the drying condition and use pigments
• Uneven sub coat layer
• achieve the required smoothness during the sub coat application
• Wash back of pigment colour coating
• avoid excess colour coating liquid
• Excessive drying between colour application
• optimize the drying conditions

6. Blooming and Sweating

• Extra moisture in the finished tablet coat
• dry properly to ensure the appropriate moisture level

7. Marbling

• Uneven coating surface
• make sure to achieve smooth coating before the polishing step

You May like Others topic:

• Sugar Coating of Tablets
• Types of Tablets

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