Rheumatoid Arthritis & Gout MCQ Quiz- GPAT Pharmacist NIPER DIMCQ Quiz-Pharmacy Total No of MCQ; .. 508 Created by PharmapediaPharmacology Rheumatoid Arthritis & Gout MCQ Quiz 1 / 23 Category: rheumatoid arthritis and goutThe most common effect of colchicine which is dose limiting is: a. Diarrhea b. Dyspepsia c. Retinal damage d. Loss of taste sensation 2 / 23 Category: rheumatoid arthritis and goutWhich of the following disease modifying anti-rheumatic drugs (DMARDs) is the drug of first choice? a. Methotrexate b. Gold compounds c. D-penicillamine d. Anakinra 3 / 23 Category: rheumatoid arthritis and goutLeflunomide is used in the treatment of a. Rheumatoid arthritis b. Dermatomyositis c. Bony metastasis d. Postmenopausal osteoporosis 4 / 23 Category: rheumatoid arthritis and goutAllopurinol specifically inhibits a. Xanthine oxidase b. Arginase c. Carbamoyl transferase d. Urease 5 / 23 Category: rheumatoid arthritis and goutLoading dose of leflunomide in rheumatoid arthritis is a. 20 mg b. 10 mg c. 100 mg d. 4000 mg 6 / 23 Category: rheumatoid arthritis and goutDrug useful for gout a. Pyrazinamide b. Rifampicin c. Allopurinol d. Naloxone 7 / 23 Category: rheumatoid arthritis and goutProbenecid interacts with? a. Streptomycin b. Ampicillin c. Vancomycin d. Erythromycin Interactions of ProbenecidIt competitively blocks active transport of organic acids at all sites especially renal tubules. It inhibits excretion of penicillin/ampicillin and increases its blood level.It also inhibits urinary excretion of cephalosporins, sulfonamides, methotrexate and indomethacin.It inhibits tubular secretion of nitrofurantoin.Salicylates, pyrazinamide and ethambutol inhibit uricosuric action of probenecid.It inhibits biliary excretion of rifampicin.8 / 23 Category: rheumatoid arthritis and goutAllopurinol potentiates the action of a. Corticosteroids b. Probenecid c. 6-Mercaptopurine d. Ampicillin Allopurinol inhibits xanthine oxidase, which metabolises 6-MP and azathioprine, so dose of 6-MP is reduced to ¼-½ if used along with allopurinol.9 / 23 Category: rheumatoid arthritis and goutWhich of the following drugs is useful in acute attack of gout? a. Furosemide b. Sulfinpyrazone c. Allopurinol d. Piroxicam 10 / 23 Category: rheumatoid arthritis and goutWhich of the following increases uric acid excretion? a. Allopurinol b. Aspirin c. Colchicine d. Probenecid 11 / 23 Category: rheumatoid arthritis and goutWhich of the following is a DMARD? a. Desferrioxamine b. Penicillamine c. Succimer d. Dimercaprol 12 / 23 Category: rheumatoid arthritis and goutA drug X is useful in the treatment of rheumatoid arthritis. It is available only in parenteral formulation and its mechanism of action is antagonism of tumor necrosis factor. Which of the following can be X? a. Cyclosporine b. Penicillamine c. Phenylbutazone d. Etanercept Infliximab and etanercept are TNF-αantagonists useful for the treatment of rheumatoid arthritis. These are administered by parenteral route. TNF-α antagonists can cause reactivation of latent tuberculosis13 / 23 Category: rheumatoid arthritis and goutA drug that is effective for rheumatoid arthritis but is not appropriate for osteoarthritis is a. Acetaminophen b. Infliximab c. Keterolac d. Rofecoxib It is a TNF-a antagonist that plays no role in osteoarthritis14 / 23 Category: rheumatoid arthritis and goutRasburicase is a newer drug used in gout. It act by: a. Decreasing urate synthesis b. Increasing urate oxidation c. Decreasing intestinal absorption of uric acid d. Increasing renal excretion of uric acid Rasburicase and pegloticase are recombinant urate oxidase enzymes that convert insoluble uric acid to soluble allantoin15 / 23 Category: rheumatoid arthritis and goutAllopurinol is useful in all of the following conditions except: a. Cancer chemotherapy induced hyperuricemia b. Hydrochlorothiazide induced hyperuricemia c. Acute gouty arthritis d. Kala –azar llopurinol is contra-indicated in acute gout16 / 23 Category: rheumatoid arthritis and goutWhich of the following drugs is useful in chronic gout but is not a uricosuric agent? a. Probenecid b. Phenylbutazone c. Sulfinpyrazone d. Allopurinol 17 / 23 Category: rheumatoid arthritis and goutMost common dose limiting adverse effect of colchicine is: a. Sedation b. Kidney damage c. Diarrhea d. Muscle paralysis 18 / 23 Category: rheumatoid arthritis and goutDrug of choice for acute gout is a. Colchicine b. Indomethacin c. Allopurinol d. Dexamethasone NSAIDs except aspirin are the agents of choice for the treatment of acute gout19 / 23 Category: rheumatoid arthritis and goutAll of the following drugs can produce hyperuricemia except: a. Ethambutol b. Pyrazinamide c. Sulfinpyrazone d. Hydrochlorothiazide 20 / 23 Category: rheumatoid arthritis and goutWhich of the following disease modifying antirheumatoid drugs is a prodrug? a. Etanercept b. Nimesulide c. Sulfasalazine d. Colchicine 21 / 23 Category: rheumatoid arthritis and goutLong term use of aspirin in rheumatoid arthritis is limited by its propensity to cause: a. Metabolic acidosis b. Hypersensitivity reactions c. Gastric mucosal damage d. Salicylism 22 / 23 Category: rheumatoid arthritis and goutAllopurinol prevents conversion of a. Hypoxanthine to xanthine b. Xanthine to hypoxanthine c. Hypoxanthine to I.M.P. d. Xanthine to uric acid e. both a & d Xanthine oxidase catalyses the conversion of hypoxanthine to xanthine as well as xanthine to uric acid. This enzyme is inhibited byallopurinol.23 / 23 Category: rheumatoid arthritis and goutWhich of the following drugs cause oligospermia? a. Leflunomide b. D-Penicillamine c. Methotrexate d. Sulfasalazine Your score isThe average score is 51% LinkedIn Facebook Twitter VKontakte 0% Restart quiz ANTISEPTIC AND DISINFACTAN MCQ Quiz part IClick here for More MCQ QuizMutation & Its Types | MicrobiologyMedical Devices Act 2017 | Pharmacy NotesConcept of Health (WHO) | Social Pharmacy NotesAlligation Method in PharmaceuticsDefinition, History, Present Status and Scope of PharmacognosyNutrition – Macronutrients and Micronutrients Please leave this field emptySign up to receive latest updates in your inbox.Email Address *You’ve been successfully subscribed to our newsletter!
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