COMPLEMENT SYSTEM
1. Classical pathway of the complement is activated by:
- a. Antigen
- b. Antibody
- c. Antigen – Antibody complex
- d. None of the above
View Answer
C
2. The alternative pathway of the complement is initiated by:
- a. Endotoxins
- b. Lipopolysaccharides
- c. Yeast cell walls
- d. All of the above
View Answer
D
3. What is the chemical nature of components of complement?
- a. Protein
- b. Lipopolysaccharide
- c. Lipid
- d. None of the above
View Answer
A
4. First component of complement which binds to antigen-antibody complex in classical pathway is:
- a. C1q
- b. C1r
- c. C1s
- d. C3
View Answer
A
5. Which complement of complement is present in the highest concentration in the serum?
- a. C1
- b. C2
- c. C3
- d. C5
View Answer
6. Factor B and Factor D are important components of:
- a. Classical pathway of complement
- b. Alternative pathway of complement
- c. Both of the above
- d. None of the above
View Answer
B
STRUCTURE AND FUNCTIONS OF IMMUNE SYSTEM
7. E-rosettes are formed by
- a. T cells
- b. B cells
- c. Macrophages
- d. Monocytes
View Answer
A
8. EAC rosettes are formed by:
- a. T cells
- b. B cells
- c. Macrophages
- d. None of the above
View Answer
B
9. CD3 receptor is present on:
- a. T cells
- b. B cells
- c. Macrophages
- d. Monocytes
View Answer
A
10. CD-4 antigen is present on:
- a. T-helper cells
- b. Macrophages
- c. Monocytes
- d. All of the above
View Answer
D
11. CD8 antigen is present on:
- a. T helper cells
- b. T suppressor cells
- c. Both of the above
- d. None of the above
View Answer
B
12. Natural killer cells play an important role in:
- a. Antiviral activity
- b. Antitumour activity
- c. Allograft rejection
- d. All of the above
View Answer
D
13. CD8 cells can recognise:
- a. MHC class I antigen
- b. MHC class II antigens
- c. MHC class III antigens
- d. All of the above
View Answer
A
14. Class II MHC antigens are present on:
- a. Macrophages
- b. Monocytes
- c. Activated T lymphocytes (CD4)
- d. All of the above
View Answer
D
15. Which of the following HLA types is associated with ankylosing spondylitis?
- a. HLA-B27
- b. HLA-DR4
- c. HLA-DP
- d. None of the above
View Answer
A
16. Which of the following HLA types is associated with rheumatoid arthritis?
- a. HLA-B27
- b. HLA-DR4
- c. HLA-A1
- d. None of the above
View Answer
B
IMMUNE RESPONSE
17. Cell mediated immunity (CMI) plays an important role in:
- a. Allograft rejection
- b. Type IV hypersensitivity reactions
- c. Graft-versus-host reaction
- d. All of the above
View Answer
D
18. B-lymphocytes which have a long lifespan and can recognize the same antigen on subsequent exposure are named:
- a. Memory cells
- b. Killer cells
- c. Natural killer cells
- d. None of the above
View Answer
A
19. The widely accepted theory of antibody formation is:
- a. Direct template theory
- b. Indirect template theory
- c. Natural selection theory
- d. Clonal selection theory
View Answer
D
20. The animal used for monoclonal antibodies production is:
- a. Mouse
- b. Guinea pig
- c. Rabbit
- d. None of the above
View Answer
A
21. The technique used for monoclonal antibodies production is:
- a. Hybridoma
- b. Rosette formation
- c. Opsonisation
- d. Immunoflorescence
View Answer
A
22. Interleukin-1 (IL-1) is principally secreted by:
- a. Macrophages
- b. Monocytes
- c. Both of the above
- d. None of the above
View Answer
C
23. Main functions of interleukin-1 (IL-1) are
- a. Stimulation of T cells for production of IL-2
- b. B cell proliferation
- c. Neutrophil chemotaxis
- d. All of the above
View Answer
D
24. Which of the following methods can be used to detect cell mediated immunity?
- a. Skin tests for delayed hypersensitivity
- b. Lymphocyte transformation test
- c. Migration inhibiting factor test
- d. All of the above
View Answer
D
25. Which of the following mechanisms can be used to induce immunological tolerance?
- a. Clonal energy
- b. Clonal deletion
- c. Suppression
- d. All of the above
View Answer
D
IMMUNODEFICIENCY DISEASES
26. DiGeorge’s syndrome is an immunodeficiency disease due to:
- a. T cell defects
- b. B cell defects
- c. Both of the above
- d. None of the above
View Answer
A
27. Which of the following defects occur in Nezelof’s syndrome.
- a. T cell defects
- b. B cell defects
- c. Both of the above
- d. None of the above
View Answer
C
28. Wiskott-Aldrich syndrome is an immunodeficiency disease which occurs due to :
- a. T cell defects
- b. B cell defects
- c. Both of the above
- d. None of the above
View Answer
C
29. Chediak-Higashi syndrome is an immunodeficiency disease which occurs due to:
- a. T cell defects
- b. B cell defects
- c. Complement disorder
- d. Diminished phagocytic activity
View Answer
D
30. Chronic graulomatous disease occurs due to deficiency of:
- a. NADPH Oxidase
- b. G6PD enzyme
- c. Both of the above
- d. None of the above
View Answer
A
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