ANTIGEN

1. Weil-Felix reaction is a serological test based on:

• a.     Heterophile antigen
• b.    Sheep brain antigen
• c.     Specific antigen
• d.    None of the above

2. Paul-Bunnell test is based on sharing of antigens between:

• a.     Sheep erythrocytes and Epstein-Barr virus
• b.    Mycoplasma and human erythrocytes
• c.     Rickettsial antigens and Proteus antigens
• d.    None of the above

ANTIBODIES – IMMUNOGLOBULINS

3. Which immunoglobulin class can pass through placenta?          

• a.     IgG
• b.    IgM
• c.     IgA
• d.    IgE

4.Which of the following immunoglobulins is heat labile?

• a.     IgG
• b.    IgM
• c.     IgA
• d.    IgE

5.Which immunoglobulin class is distributed maximum intravascularly?

• a.     IgG
• b.    IgM
• c.     IgA
• d.    IgE

6. J chain is present in:

• a.     IgG
• b.    IgM
• c.     IgD
• d.    IgE

7. Which is the first immunoglobulin to appear in response to an antigen?

• a.     IgG
• b.    IgM
• c.     IgA
• d.    IgE

8. .Which immunoglobulin class has maximum concentration in the human body?

• a.     IgG
• b.    IgM
• c.     IgA
• d.    IgE

9. Presence of which immunoglobulin class in serum is a useful indicator for diagnosis of congential infections?

• a.     IgG
• b.    IgM
• c.     IgA
• d.    IgE

10. Which is the earliest immunoglobulin to be synthesized by the foetus?

• a.     IgG
• b.    IgM
• c.     IgA
• d.    IgE

11. Which immunoglobulin class is involved in type I hypersensitivity reaction?

• a.     IgG
• b.    IgM
• c.     IgA
• d.    IgE

12. Which immunoglobulin class can bind to mast cells?

• a.     IgG
• b.    IgM
• c.     IgA
• d.   IgE

ANTIGEN-ANTIBODY REACTIONS

13.Which immunoglobulin class is the most efficient to produce agglutination reaction?

• a.     IgG
• b.    IgM
• c.     IgA
• d.    IgE

14. Which immunoglobulin class is the most efficient to produce precipitation reaction?

• a.    IgG
• b.    IgM
• c.     IgA
• d.    IgE

79.Ring test is used for:

• a.     C-reactive protein test
• b.    Streptococcal grouping by Lancefield technique
• c.     Both of the above
• d.    None of the above

15.VDRL test is an example of:           

• a.     Agglutination test
• b.    Flocculation test
• c.     Immunofluorescence
• d.    All of the above

16.Radial immunodifusion can be used to estimate the following immunoglobulin classes:

• a.     IgG
• b.    IgM
• c.     IgA
• d.   All of the above

17.Counter immune electrophoresis is used for detecting:

• a.     Hepatitis B antigens
• b.    Cryptococcal antigens
• c.     Neisseria meningitides
• d.   All of the above

18. Tube agglutination test is used for serologicall diagnosis of:

• a.     Enteric fever
• b.    Infectious monomucleosis
• c.     Typhus fever
• d.    All of the above

19.Which of the following is/are example/s of heterophile agglutination test?

• a.     Weil-Felix reaction
• b.    Paul-Bunnel test
• c.     Streptococcus MG agglutination test
• d.    All of the above

20.Which of the following is/are example/s of passive agglutination test?

• a.     Latex agglutination test
• b.    Haemagglutination test
• c.     Coagglutination
• d.    All of the above

21.Which of the following is/are example/s of neutralization test?

• a.     Schick test
• b.    Antistreptolysin ‘O’ test
• c.     Nagler reaction
• d.    All of the above

22.Direct immunofluorescence test may be used for detection of:              

• a.    Rabies virus antigens
• b.    Antibodies in syphilis
• c.     Both of the above
• d.    None of the above

23.Indirect immunofluorescence test may be used for detection of:          

• a.     Rabies virus antigens
• b.    Antibodies in syphilis
• c.     Both of the above
• d.    None of the above

24.ELISA can be used for detection of antigens and/or antibodies in:

• a.     HIV
• b.    Rotavirus
• c.     Hepatitis B virus
• d.    All of the above

25.The technique of immunoblotting to analyse RNA is named:

• a.     Southern blot
• b.    Northern blot
• c.     Western blot
• d.    None of the above

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