1.Among the propellants used in aerosols, one of the following is used for topical pharmaceutical aerosols
(a) Trichloro monofluoro methane
(b) Dichloro difluoro methane
(c) Dichloro tetra fluoro ethane
(d) Propane
2.Depending on the nature of the product concentrate, the aerosol can be filled by
a)cold-filling
b)pressure-filling
c)both of these
d)none of these
3.Manufacture of pharmaceutical aerosols can be done by
a)Pressure filling apparatus
b)Cold filling apparatus
c)Compressed gas filling apparatus
d)All of these
4.It consists of a pressure burette capable of metering small volumes of liquefied gas into the aerosol container under pressure. Identify
a)Pressure filling apparatus
b)Cold filling apparatus
c)Compressed gas filling apparatus
d)All of these
5.In Pressure filling apparatus the trapped air escapes out from
a)upper valve
b)lower valve
c)middle valve
d)all of these
6.In Pressure filling apparatus the propellant stops flowing when the pressure of burette and container becomes
a)equal
b)0
c)1
d)none of these
7.In Pressure filling apparatus the pressure exerted by ____ helps in the flow of the propellant into the container
a)Hydrogen
b)Argon
c)CFC
d)Nitrogen
8.Which of the following is not a disadvantage of pressure filling apparatus?
a)Certain types of metering valves can be handled only by the cold filling process or through use of an under the cap filler and valve crimper
b)Process is slower than Cold filling method
c)Loss of propellant is less
d)None of these
9..Which of the following is/are advantages of pressure filling apparatus?
a)Solutions, emulsions, suspensions can be filled by this method as chilling does not occur
b)Contamination due to moisture is less
c)High production speed can be achieved
d)All of these
10.It consist of an insulated box fitted with copper tubings and the tubings are coiled to increase the area exposed to cooling. Identify
a)Pressure filling apparatus
b)Cold filling apparatus
c)Compressed gas filling apparatus
d)All of these
11.Before use the insulated box in cold filling apparatus should be filled with
a) dry ice
b)acetone
c)ethanol
d)a and b
12.Hydrocarbon propellant cannot be filled into aerosol containers using cold filling apparatus because large amount of propellant escapes out and vaporizes. This may lead to formation of an explosive mixture.
a)true
b)false
13.Advantage of cold filling apparatus is
a)Solutions, emulsions, suspensions can be filled by this method as chilling does not occur
b)Contamination due to moisture is less
c)High production speed can be achieved
d)Easy process
14.This apparatus consists of delivery gauge. identify
a)Pressure filling apparatus
b)Cold filling apparatus
c)Compressed gas filling apparatus
d)All of these
15.Which gas can be is used if more amount of gas is required in Compressed gas filling apparatus?
a)Carbon dioxide
b)Nitrous oxide
c)Nitrogen
d)a and b
16. The dip tube in aerosol container is made from one of the following. Choose thecorrect one
a) Polypropylene
b) Glass
c) Stainless steel
d) Aluminium
17. Tri- chloro-mono-fl uoro- methane…?
A. Propellant 11
B. Propellant 12
C. Propellant 13
D. Propellant 14
18. Hydrocarbons can be used for water basedaerosols and topical used propellant A-108 is?
A. Isobutane
B. Butane
C. Isohexane
D. Propane
19. Propellant 12 in pharmaceutical aerosols..?
A. Tri-chloro-mono-fl ouro butane
B. Di-chloro-di-fl ouro methane
C. Tri-chloro-mono-fl ouro methane
D. Di-chloro-tri-fl ouro ethane
20. Aerosols container must be able to withstand pressure as high as?
A. 140-180 psig(pounds per square inch gauge)
B. 100-120 psig
C Aluminium
D all the above
21. Metered-dose inhalers”Advair inhaler used in asthma contain which drug ?
A. Flutocasone
B. Dexamethasone
C. Albuterol
D. Flunisolide
22. Valve acceptance limit for deliveries more than55 to 200 microlitres for the testing procedure of aerosols is.
A. +/10%
B. +/ 15%
C. +/_ 7.5%
D. +/_ 5%
23. Which connects Valve to container
A. Valve body (or)housing
B. Ferrule(or) mounting cup
C. Stem
D. Gasket
Answer Key
1. d
2. c)both of these
3. d)All of these
4. a)Pressure filling apparatus
5. a)upper valve
6. a)equal
7. d)Nitrogen
8. c)Loss of propellant is less
9. d)All of these
10. b)Cold filling apparatus
11. d)a and b
12. a)true
13. d)Easy process
14. c)Compressed gas filling apparatus
15. d)a and b
16. a
17. a
18. d
19. b
20. a
21. a
22. a
23. b
Pingback: Pharmaceutical Aerosol Products | Pharmacy Notes | The Pharmapedia