Pharmacokinetics MCQ Quiz with Answer Key- Pharmacist & DI

Welcome to the Pharmacokinetics MCQ Quiz with Answers, specially designed for B.Pharmacy, D.Pharmacy, Pharm.D, GPAT, NIPER, Drug Inspector, and Pharmacist competitive examinations. This quiz includes important multiple-choice questions on Volume of Distribution (Vd), Bioavailability, Clearance, Loading Dose, First-Order Kinetics, Cytochrome P450, Microsomal Enzyme Inducers & Inhibitors, Drug Metabolism, Prodrugs, and Drug Elimination. These questions are frequently asked in recruitment examinations such as UPSC Drug Inspector, BFUHS Pharmacist, AIIMS, RRB Pharmacist, ESIC, DSSSB, CGHS, ISRO, NTPC, NCL, CCL, BCCL, CRPF, ITBP, SSB, CISF, HPSSSB, GSSSB, GPSSSB, and various State Pharmacist and Drug Inspector examinations. Attempt this free Pharmacokinetics MCQ test to strengthen your conceptual understanding, improve your exam preparation, and evaluate your performance with detailed answers and explanations.

Pharmacology MCQ Quiz

Q.61) Apparent volume of distribution (Vd) of a drug exceeds total body fluid volume, if a drug is:

A) Sequestrated in body tissues B) Slowly eliminated from body C) Poorly soluble in plasma D) Highly bound to plasma proteins

Q.62) Which of the following drug acts as microsomal enzyme inhibitor:

A) Rifampicin B) Cimetidine C) Phenobarbitone D) Phenytoin

Q.63) Which of the following is an inducer of microsomal enzymes:

A) Phenobarbitone B) Paracetamol C) Digoxin D) Penicillin

Q.64) Removal of acidic drugs from body is done by using:

A) Ammonium chloride B) Sodium bicarbonate C) Hydrochloric acid D) Citric acid

Q.65) Very high first pass metabolism is seen in:

A) Digoxin B) Dicoumarol C) Propranolol D) Practalol

Q.66) Pharmacokinetics is:

A) Study of absorption, distribution, binding storage/biotransformation and excretion of the drug B) Study of physiological and biochemical effects of drugs C) Application of pharmacological information together with knowledge of the disease D) Scientific study of drugs in humans

Q.67) Which one of the following is a pro-drug?

A) Dopamine B) Epinephrine C) Levodopa D) Prednisolone

Q.68) Which one of the following is a prodrug?

A) Dopamine B) Enalapril C) Ampicillin D) Prednisolone

Q.69) ‘Bioavailability’ is defined as:

A) The volume of plasma completely cleared of a specific compound per unit time and measured as a test of kidney function B) The percentage of drug that is reached in the systemic circulation after its administration C) Both D) None

Q.70) Volume of distribution (Vd) of drug is given by:

A) Vd= Dose administrated i.v/Plasma concentration B) Vd = Maximum tolerated dose/Dose administered i.v. C) Vd = Dose administered i.v./Total lipid solubility D) Vd = t1/2 / Dose administered i.v.

Q.71) Redistribution phenomenon is seen in:

A) Halothane B) Ether C) Thiopentone D) All

Q.72) Sulphonamide is conjugated with:

A) Acetylation B) Methylation C) Hydroxylation D) None

Q.73) Which of the following statements is correct?

A) Most drugs are absorbed in ionized form B) Basic drugs are generally bound to plasma albumin C) Microsomal enzymes are located in the mitochondria of hepatic cells D) Blood brain barrier is deficient at the chemoreceptor trigger zone

Q.74) Non-synthetic phase I reaction for drug detoxification is:

A) Glucuronidation B) Acetylation C) Methylation D) Oxidation

Q.75) Which of the following is NOT a prodrug?

A) Enalapril B) Imipramine C) Sulphasalazine D) Cyclophosphamide

Q.76) Loading dose of a drug is given:

A) To achieve steady state concentration in short time B) For drugs with short t½ C) To reduce complications D) All of these

Q.77) Alkalinization of urine is done for:

A) Weak acid drugs B) Weak basics drugs C) Strong acidic drugs D) Strong basic drugs

Q.78) Loading dose depends on the following factors except:

A) Drug concentration to be achieved B) Volume of distribution C) Clearance of the drug D) Bioavailability of drug

Q.79) Which of the following is NOT an oxidative type of drug metabolism?

A) Deamination B) N-oxidation C) N-dealkylation D) Glucuronidation

Q.80) Which of the following is a Phase I metabolic reaction?

A) Hydroxylation B) Conjugation C) Glucuronidation D) Sulfation

Q.81) In drug metabolism, hepatic cytochrome P-450 system is responsible for:

A) Phase I reactions (hydrolysis, oxidation, reduction etc.) only B) Phase II reactions (conjugation, synthesis etc.) only C) Both phase I and II reactions D) Converting hydrophilic metabolites to lipophilic Metabolites

Q.83) One of the potential microsomal enzymes inhibitor drug is:

A) Phenobarbitone B) Griseofulvin C) Sodium valproate D) Phenytoin

Q.85) One of the potent microsomal enzyme inducer drug is:

A) Captopril B) Erythromycin C) Rifampicin D) Cimetidine

Q.86) Alkalinization of urine is required to treat toxicity of all except:

A) Sulfonamides B) Amphetamine C) Salicylates D) Barbiturates

Q.87) Cytochrome P450 most commonly involved in drug metabolism:

A) CYP 3A4 B) CYP 1AI C) CYP 2E1 D) CYP 2D6

Q.88) Which of the following drugs binds to albumin?

A) Penicillin B) Lidocaine C) Propanolol D) Verapamil

Q.89) Which of the following is an enzyme inhibitor?

A) Ketoconazole B) Rifampicin C) Tolbutamide D) Phenobarbitone

Q.90) Which of the following parameters signifies the effective drug removal from the body?

A) Clearance B) Bioavailability C) Safety D) Volume of distribution

Q.91) True statement about first order kinetics is:

A) A constant amount of a drug is eliminated in unit time B) The half-life increases with an increase in dose C) The rate of elimination is constant D) The rate of elimination is proportional to the plasma concentration

Q.93) True statement regarding first-order kinetics is:

A) Rate of elimination is independent of plasma concentration B) A constant proportion of plasma concentration is eliminated per unit of time C) Half life increases with dose D) Clearance decreases with dose

Q.94) After I.V. drug administration, elimination of a drug depends on: (Note: Select any of the true statements)

A) Lipid solubility B) Volume of distribution C) Clearance D) Drug concentration

Q.95) A 70 kg man was given a drug in a dose of 100 mg/kg body weight. Its t1/2 is 10 hours, initial plasma concentration is 1.9 mg/ml. True statement is:

Q.96) Amount of a drug X administered to a patient is 4.0 g and its plasma concentration is found to be 50 mg/ml, what will be the volume of distribution of drug X?

A) 100L B) 80L C) 60L D) 50L

Q.97) Maintenance dose rate of a drug depends primarily on:

A) Volume of distribution B) Half life C) Lipid solubility D) Total body clearance

Q.98) Rate of elimination of a new drug is 20 mg/hr at a steady state plasma concentration of 10 mg/L, then its renal clearance will be:

A) 0.5 L/hr B) 2.0 L/hr C) 5.0 L/hr D) 20 L/hr

Q.100) Ram Prashad is admitted to Guru Teg Bahadur Hospital with respiratory infection for which antibiotic tobramycin is ordered. The clearance and Vd of tobramycin in him are 160 ml/min and 40 L, respectively. If you wish to give Ram Prashad an intravenous loading dose to achieve the therapeutic plasma concentration of 4 mg/L rapidly, how much should be given?

A) 0.1 mg B) 10 mg C) 115.2 mg D) 160 mg

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