🎓

Master Your Pharmacy Exams

Welcome to your ultimate exam preparation resource! If you are studying for your upcoming pharmacist or drug inspector exams, consistent practice is the key to success.

Below, you will find a comprehensive set of General Pharmacology MCQs designed to challenge your understanding of crucial medical concepts, including pharmacokinetics, therapeutic drug monitoring, and the phases of clinical trials.

Take your time, select the best answers, and click the button at the bottom of the page to reveal your total score. Good luck!

Explore All Pharmacology Quizzes ➔

Pharmacology MCQ Quiz

Q.151) Which of the following does not act as second messenger?

A) Cyclic AMP B) Inositol trisphosphate C) Diacylglycerol D) G proteins

Q.152) ‘Drug efficacy’ refers to:

A) Effectiveness of drug in life threatening conditions B) The maximal intensity of response that can be produced by the drug C) The dose of the drug needed to produce half maximal effect D) The minimum dose of the drug needed to produce toxic effect

Q.153) A 56 yr old man, Surender with heart failure is to be treated with a diuretic drug. Drugs A and B have same mechanism of action. Drug A in dose of 50 mg produces the same magnitude of diuresis as 500 mg of drug B. This suggests that:

A) Drug B is less efficacious than drug A B) Drug A is more potent than drug B C) Drug A is a safer drug than drug B D) Drug A will have shorter duration of action than drug

Q.154) Which of the following has cytoplasmic receptor:

A) Epinephrine B) Insulin C) FSH D) Cortisol

Q.155) Which of the following is true for receptor action of a drug:

A) An antagonist has both intrinsic activity and affinity for receptor B) An antagonist has affinity but no intrinsic activity for receptor C) A partial antagonist has no intrinsic activity or affinity for receptor D) Intrinsic activity and affinity are not important for drug action

Q.156) All of the following cross plasma membrane except:

A) Epinephrine B) Thyroxine C) Androstenedione D) Estrogen

Q.157) G-coupled protein receptor is:

A) Metabotropic receptors B) Ionic receptors C) Kinase-linked receptors D) Nuclear receptors

Q.158) About inverse agonism, true is:

A) Action on the target receptors is similar to that of agonist B) Binds to the same receptor binding-site as an agonist for that receptor but exerts the opposite pharmacological effect C) Acts on receptors which do not have agonist D) None

Q.159) Antagonism between acetylcholine and atropine:

A) Competitive antagonism B) Physiological antagonism C) Noncompetitive antagonism D) None

Q.160) Michaelis Menton constant is:

A) Concentration of drug at which the reaction velocity is half of maximum B) Concentration of drug at which the reaction velocity is maximum C) Both D) None

Q.161) When two different chemicals act on two different receptors and their response is opposite to each other on the same cell, this is called as:

A) Physiological antagonism B) Chemical antagonism C) Reversible antagonism D) Competitive antagonism

Q.162) Agonist is having:

A) Affinity with intrinsic activity is 1 B) Affinity with intrinsic activity is 0 C) Affinity with intrinsic activity is -1 D) None

Q.163) Therapeutic monitoring of plasma level of drug is done when using all of the following drugs except:

A) Warfarin B) Gentamicin C) Cyclosporine D) Phenytoin

Q.164) Therapeutic Drug Monitoring (TDM) involves measurement of plasma concentrations of drugs to find whether the drug levels are within the therapeutic range or not. For TDM to be clinically useful the following criteria should be fulfilled:

A) There should be good relationship between plasma concentration and drug dosage B) The relationship between plasma drug concentration and therapeutic response and/or toxicity should be poor C) When pharmacodynamic tolerance is suspected D) When the clinical response cannot be easily monitored

Q.165) Therapeutic index is a measure of:

A) Safety B) Potency C) Efficacy D) Selectivity

Q.166) Therapeutic drug monitoring is required in all except:

A) Phenytoin B) Metformin C) Tacrolimus D) Cyclosporin

Q.167) Drugs having narrow theraputic index are: (Select any correct option)

Q.168) Therapeutic drug monitoring is required for:

A) Prodrugs B) Levodopa C) Lithium carbonate D) MAO inhibitors

Q.169) Therapeutic drug monitoring of plasma concentrations of antihypertensive drugs is not practiced because:

A) Determination of plasma level of these drugs is quite tedious and long process B) It is easier to measure the effect of these drugs C) Antihypertensive effect do not increase linearly with the dose D) All antihypertensive drugs are prodrugs

Q.170) Drug having very narrow therapeutic range is:

A) Lithium B) Sertraline C) Roboxetine D) Dothiepin

Q.171) Which of the following drug needs serum level monitoring?

A) Lorazepam B) Lithium C) Amitryptylline D) Haloperidol

Q.172) Which one of the following drugs has narrow therapeutic range?

A) Propanolol B) Phenytoin C) Piroxicam D) Prazosin

Q.173) Therapeutic index is an assessment of:

A) Potency of a drug B) Onset of action C) Duration of action D) Margin of safety

Q.174) Therapeutic Index is:

A) ED50/LD50 B) LD50/ED50 C) ED50 – LD50 D) ED50 × LD50

Q.175) The ratio of the dose that produces toxicity to the dose that produces a clinically desired or effective response in a population of individual is known as:

A) Efficacy B) Potency C) Therapeutic index D) Partial agonist

Q.176) Plasma drug monitoring is done for:

A) Drug with high safety margin B) Drug with low safety margin C) Drug with high therapeutic index D) None

Q.177) ED50 is used for determining:

A) Potency B) Efficacy C) Safety D) Toxicity

Q.178) Design of the study aimed to assess the maximum tolerable dose of a new drug is best described as:

A) Case control study (AIIMS May 2013) B) Phase II Randomized control trial (RCT) C) Phase I trial D) Phase III Randomized control trial (RCT)

Q.179) Comparison of efficacy of a new drug B with an existing drug A is done in which phase of clinical trials?

A) Phase I B) Phase II C) Phase III D) Phase IV

Q.180) Pharmacovigilance means:

A) Monitoring of drug safety B) Monitoring of unethical trade of drugs C) Monitoring pharma students D) Monitoring drug efficacy

Q.181) True about orphan drug is:

A) Developed for orphans B) Drugs used very rarely C) Drugs used for rare diseases D) Rare drug for common diseases

Q.182) True statement about phase 2 clinical trials is:

A) Large number of healthy volunteers are studied B) Used to determine maximum tolerated dose C) Used to determine efficacy D) Used to determine toxicity

Q.183) When a drug is evaluated for its usefulness in controlled conditions, it is termed as a trial signifying:

A) Efficacy B) Effectiveness C) Efficiency D) Effect modification

Q.184) In which of the following phases of clinical trial of drugs, ethical clearance is not required?

A) Phase I B) Phase II C) Phase III D) Phase IV

Q.185) Good clinical practice (GCP) is not required in:

A) Preclinical phase B) Phase I trial C) Phase II studies D) Phase IV studies

Q.186) Which of the following is true of ‘placebo’?

A) Placebo is a dummy medication B) Placebo is the inert material added to the drug for making tablets C) Placebos do not produce any effect D) All patients respond to placebo

Q.187) Which of the following statements best describes an ‘orphan drug’?

A) It is a drug which acts on orphanin receptors B) It is a very cheap drug C) It is a drug which has no therapeutic use D) It is a drug required for treatment or prevention of a rare disease

Q.188) With respect to clinical trials of new drugs, which of the following is most correct?

A) Phase I involves the study of a small number of normal volunteers by highly trained clinical pharmacologists B) Phase II involves the use of the new drug in a large number of patients (1000-5000) who have the disease to be treated C) Phase III involves the determination of the drug’s therapeutic index by the cautious induction of toxicity D) Phase IV involves the detailed study of toxic effects that have been discovered in phase III.

Q.189) In which of the following phases of clinical trials, healthy normal human volunteers participate:

A) Phase-I B) Phase-II C) Phase-III D) Phase-IV

Q.190) There are some undesirable but unavoidable pharmacodynamic effects of a drug, which are known as:

A) Toxic effects B) Idiosyncrasy C) Side effects D) Intolerance

Q.191) The aim of post-marketing studies is:

A) Efficacy of the drug B) Dosage of the drug C) Deals with alteration of the drug includes absortion, distribution, binding/storage D) Safety and comparisons with other medicines

Q.192) In which phase of clinical trials, post-marketing surveillance of a drug is carried out:

A) Phase I B) Phase II C) Phase III D) Phase IV

Q.193) Type A (augmented) adverse drug reactions are characterized by all EXCEPT:

A) Qualitatively abnormal responses to the drug B) Predictable from the drug’s known pharmacological or toxicological effects C) Generally dose-dependent D) Usually common

Q.194) In pregnancy, all of the following drugs are contraindicated except:

A) ACE Inhibitors B) Angiotensin Receptor Blockers C) Proplythiouracil D) Thalidomide

Q.195) A newborn baby was born with phocomelia. It results due to which drug taken by mother during pregnancy?

A) Tetracycline B) Thalidomide C) Warfarin D) Alcohol

Q.196) Which of the following drugs can be given safely in pregnancy:

A) Propylthiouracil B) Methotrexate C) Warfarin D) Tetracycline

Q.197) All of the following drugs undergo hepatic metabolism before excretion except:

A) Phenytoin B) Diazepam C) Penicillin G D) Cimetidine

Q.198) All the following drugs can cross placenta except:

A) Phenytoin B) Diazepam C) Morphine D) Heparin

Q.199) All are reasons for alteration of drug dosage in the elderly except:

A) They have decreasing renal function with age B) They are lean and their body mass is less C) Have increased baroreceptor sensitivity D) Body water is decreased

Q.200) True about the teratogenicity of a drug is all except:

A) Characteristic set of malformations indicating selectivity for certain target organs is seen B) Heparin is highly teratogenic drug C) Related to the dose of the teratogenic drug D) Affects specifically at a particular phase of development of the fetus

Finished the Quiz?

Check your total score below (1 Mark for each correct answer).

📚 Explore More Pharmacy Resources at The Pharmapedia

Boost your preparation with Previous Year Papers, Latest Pharmacist & Drug Inspector Syllabus, Chapter-wise Pharmacy MCQs, Job Notifications, and Complete Pharmacy Notes.

📄