| Chapter | Topic |
| 1. | Introduction to human body Cellular level of organization Tissue level of organization |
| 2. | Integumentary system Skeletal system Joints |
| 3. | Body fluids and blood Lymphatic system |
| 4. | Peripheral nervous system: Special senses |
| 5. | Cardiovascular system |
| Chapter | Topic |
| 1. | (a) Pharmaceutical analysis (b) Pharmaceutical analysis (c)Pharmacopoeia, Sources of impurities in medicinal agents,limit tests. |
| 2. | Acid base titration Non aqueous titration |
| 3. | Precipitation titrations Complexometric titration Gravimetry diazotisation titration |
| 4. | Redox titrations Electrochemical methods of analysis • Conductometry • Potentiometry • Polarography |
| Chapter | Topic |
| 1. | Historical background and development of profession of pharmacy Dosage forms Prescription Posology |
| 2. | Pharmaceutical calculations Powders Liquid dosage forms |
| 3. | Monophasic liquids: Biphasic liquids: Suspensions & Emulsion |
| 4. | Suppositories: Pharmaceutical incompatibilities |
| 5. | Semisolid dosage forms |
| Unit | Topic |
| 1. | Impurities in pharmaceutical substances |
| 2. | General methods of preparation, assay for the compounds superscripted with asterisk (*), properties and medicinal uses of inorganic compounds belonging to the following classes • Acids, Bases and Buffers • Major extra and intracellular electrolytes • Dental products |
| 3. | Gastrointestinal agents- • Acidifiers • Antacid • Cathartics • Antimicrobials |
| 4. | Miscellaneous compounds • Expectorants • Emetics: • Haematinics • Poison and Antidote: • Astringents |
| 5. | Radiopharmaceuticals |
| Unit | Topic |
| 1. | Communication Skills Barriers to communication Perspectives in Communication |
| 2. | Elements of Communication Communication Styles |
| 3. | Basic Listening Skills Effective Written Communication Writing Effectively |
| 4. | Interview Skills Giving Presentations |
| 5. | Group Discussion |
| REMEDIAL BIOLOGY | Unit | Topic |
| 1. | Living world Morphology of Flowering plants |
|
| 2. | Body fluids and circulation Digestion and Absorption Breathing and respiration |
|
| 3. | Excretory products and their elimination Neural control and coordination Chemical coordination and regulation Human reproduction |
|
| 4. | Plants and mineral nutrition Photosynthesis |
|
| 5. | Plant respiration Plant growth and development Cell – The unit of life Tissues |
| REMEDIAL MATHEMATICS | Unit | Topic |
| 1. | Partial fraction Logarithms Function Limits and continuity |
|
| 2. | Matrices and Determinant | |
| 3. | Calculus | |
| 4. | Analytical Geometry | |
| 5. | Differential Equations Laplace Transform |
| Unit | Topic |
| 1. | Nervous system |
| 2. | Digestive system Energetics |
| 3. | Respiratory system Urinary system |
| 4. | Endocrine system |
| 5. | Reproductive system Introduction to genetics |
| Unit | Topic |
| 1. | Classification, nomenclature and isomerism |
| 2. | Alkanes*, Alkenes* and Conjugated dienes* E1 E2 reactions SP2 SP3 hybridiazation |
| 3. | Alkyl halides→ SN1 versus SN2 reactions Alcohols |
| 4. | Carbonyl compounds* (Aldehydes and ketones) |
| 5. | Carboxylic acids Aliphatic amines |
| Unit | Topic |
| 1. | Biomolecules Bioenergetics |
| 2. | Carbohydrate metabolism Biological oxidation |
| 3. | Lipid metabolism Amino acid metabolism |
| 4. | Nucleic acid metabolism and genetic information transfer |
| 5. | Enzymes |
| Unit | Topic |
| 1. | Basic principles of Cell injury and Adaptation Basic mechanism involved in the process of inflammation and repair |
| 2. | Cardiovascular System Respiratory system Renal system |
| 3. | Haematological Diseases Endocrine system diseases Nervous system disorder Gastrointestinal system disease |
| 4. | Inflammatory bowel diseases, jaundice, hepatitis (A,B,C,D,E,F) alcoholic liver disease. Disease of bones and joints Principles of cancer |
| 5. | Infectious diseases STD |
| Unit | Topic |
| 1. | Number system Concept of Information Systems and Software |
| 2. | Web technologies Introduction to databases |
| 3. | Application of computers in Pharmacy Diagnostic System, Lab-diagnostic System, Patient Monitoring System, Pharma Information System |
| 4. | Bioinformatics |
| 5. | Computers as data analysis in Preclinical development |
| Unit | Topic |
| 1. | Multidisciplinary nature of environmental studies Renewable and non-renewable resources & Natural resources |
| 2. | Ecosystems |
| 3. | Environmental Pollution: Air pollution; Water pollution; Soil pollution |
| Unit | Topic |
| 1. | Benzene and its derivatives |
| 2. | Phenols; Aromatic Amines, Aromatic Acids |
| 3. | Fats and Oils |
| 4. | Polynuclear hydrocarbons |
| 5. | Cyclo alkanes |
| Unit | Topic |
| 1. | Solubility of drugs |
| 2. | States of Matter and properties of matter Physicochemical properties of drug molecules |
| 3. | Surface and interfacial phenomenon |
| 4. | Complexation and protein binding |
| 5. | pH, buffers and Isotonic solutions: |
| Unit | Topic |
| 1. | Introduction & history of microbiology Introduction to Prokaryotes and Eukaryotes Identification, Classification, Nutritional, culture media, cultivation of bacteria Microscope |
| 2. | Staining techniques Methods of Sterilization & Sterility indicators |
| 3. | Fungi & Virus- morphology, classification, reproduction/replication and cultivation Disinfectants Evaluation of bactericidal & Bacteriostatic Sterility testing of products |
| 4. | Aseptic Area, Clean Area classification Microbiological Assay of Vitamin & Antibiotic |
| 5. | • Types of spoilage, factors affecting the microbial spoilage of pharmaceutical products, sources and types of microbial contaminants, assessment of microbial contamination and spoilage. • Preservation of pharmaceutical products using antimicrobial agents, evaluation of microbial stability of formulations. • Growth of animal cells in culture, general procedure for cell culture, Primary, established and transformed cell cultures. • Cell cultures in pharmaceutical industry and research. |
| Unit | Topic |
| 1. | Flow of fluids Size Reduction Size Separation |
| 2. | Heat Transfer Evaporation Distillation |
| 3. | Drying Mixing |
| 4. | Filtration Centrifugation |
| 5. | Materials of pharmaceutical plant construction, Corrosion and its Prevention |
| Unit | Topic |
| 1. | Stereo isomerism, Optical Isomerism |
| 2. | Geometrical isomerism |
| 3. | Heterocyclic compounds |
| 4. | Synthesis, reactions and medicinal uses of following compounds/derivatives • Pyrazole, Imidazole, Oxazole and Thiazole. • Pyridine, Quinoline, Isoquinoline, Acridine and Indole. Basicity of pyridine • Synthesis and medicinal uses of Pyrimidine, Purine, azepines and their derivatives |
| 5. | Reactions of synthetic importance • Metal hydride reduction (NaBH4 and LiAlH4), Clemmensen reduction, Birch reduction, Wolff Kishner reduction. • Oppenauer-oxidation and Dakin reaction. • Beckmanns rearrangement and Schmidt rearrangement. • Claisen-Schmidt condensation |
| Unit | Topic |
| 1. | Introduction to Medicinal Chemistry History and development of medicinal chemistry Physicochemical properties in relation to biological action Drug metabolism |
| 2. | Drugs acting on Autonomic Nervous System • Adrenergic Neurotransmitters • Sympathomimetic agents: SAR of Sympathomimetic agents • Adrenergic Antagonists: |
| 3. | Cholinergic neurotransmitters Parasympathomimetic agents: SAR of Parasympathomimetic agents (Direct & Indirect acting agent) Cholinesterase reactivator Solanaceous alkaloids and analogues Synthetic cholinergic blocking agents |
| 4. | Drugs acting on Central Nervous System A. Sedatives and Hypnotics B. Antipsychotics C. Anticonvulsants |
| 5. | Drugs acting on Central Nervous System General anesthetics Narcotic and non-narcotic analgesics |
| Unit | Topic |
| 1. | Colloidal dispersions |
| 2. | Rheology & Deformation of solids |
| 3. | Coarse dispersion |
| 4. | Micromeretics |
| 5. | Drug stability |
| Unit | Topic |
| 1. | General Pharmacology, Route of Drug Absorption & Pharmacokinetics |
| 2. | Pharmacodynamics, ADR, Drug interactions, Drug Discovery & Clinical evaluation of New Drug & pharmacovigilance. |
| 3. | Pharmacology of drugs acting on peripheral nervous system |
| 4. | Pharmacology of drugs acting on central nervous system |
| 5. | Pharmacology of drugs acting on central nervous system |
| Unit | Topic |
| 1. | Introduction to Pharmacognosy Classification of drugs Quality control of Drugs of Natural Origin |
| 2. | Cultivation, Collection, Processing and storage of drugs of natural origin Conservation of medicinal plants |
| 3. | Plant tissue culture |
| 4. | Pharmacognosy in various systems of medicine Introduction to secondary metabolites |
| 5. | Fibers – Cotton, Jute, Hemp Hallucinogens, Teratogens, Natural allergens Primary metabolites: General introduction, detailed study with respect to chemistry, sources, preparation, evaluation, preservation, storage, therapeutic used and commercial utility as Pharmaceutical Aids and/or Medicines for the following Primarymetabolites: Carbohydrates: Acacia, Agar, Tragacanth, Honey Proteins and Enzymes : Gelatin, casein, proteolytic enzymes (Papain, bromelain, serratiopeptidase, urokinase, streptokinase, pepsin). Lipids(Waxes, fats, fixed oils) : Castor oil, Chaulmoogra oil, Wool Fat, Bees Wax Marine Drugs: |
| Unit | Topic |
| 1. | Classification, mechanism of action, uses of drugs mentioned in the course, Structure activity relationship of selective class of drugs as specified in the course and synthesis of drugs superscripted (*) • H1–antagonists: Diphenhydramine hydrochloride*, Dimenhydrinate, Doxylamines cuccinate, Clemastine fumarate, Diphenylphyraline hydrochloride, Tripelenamine hydrochloride, Chlorcyclizine hydrochloride, Meclizine hydrochloride, Buclizine hydrochloride, Chlorpheniramine maleate, Triprolidine hydrochloride*, Phenidamine tartarate, Promethazine hydrochloride*, Trimeprazine tartrate, Cyproheptadine hydrochloride, Azatidine maleate, Astemizole, Loratadine, Cetirizine, Levocetrazine Cromolyn sodium • H2-antagonists: Cimetidine*, Famotidine, Ranitidin. • Gastric Proton pump inhibitors: Omeprazole, Lansoprazole, Rabeprazole, Pantoprazole • Anti-neoplastic agents: • Alkylating agents: Meclorethamine*, Cyclophosphamide, Melphalan, Chlorambucil, Busulfan, Thiotepa |
| 2. | Anti-anginal: Vasodilators: Amyl nitrite, Nitroglycerin*, Pentaerythritol tetranitrate, Isosorbide dinitrite*, Dipyridamole. Calcium channel blockers: Verapamil, Bepridil hydrochloride, Diltiazem hydrochloride, Nifedipine, Amlodipine, Felodipine, Nicardipine, Nimodipine. Diuretics: Carbonic anhydrase inhibitors: Acetazolamide*, Methazolamide, Dichlorphenamide. Thiazides: Chlorthiazide*, Hydrochlorothiazide, Hydroflumethiazide, Cyclothiazide, Loop diuretics: Furosemide*, Bumetanide, Ethacrynic acid. Potassium sparing Diuretics: Spironolactone, Triamterene, Amiloride. Osmotic Diuretics: Mannitol Anti-hypertensive Agents: Timolol, Captopril, Lisinopril, Enalapril, Benazepril hydrochloride, Quinapril hydrochloride, Methyldopate hydrochloride,* Clonidine hydrochloride, Guanethidine monosulphate, Guanabenz acetate, Sodium nitroprusside, Diazoxide,Minoxidil, Reserpine, Hydralazine hydrochloride. |
| 3. | Anti-arrhythmic Drugs: Quinidine sulphate, Procainamide hydrochloride, Disopyramide phosphate*, Phenytoin sodium, Lidocaine hydrochloride, Tocainide hydrochloride, Mexiletine hydrochloride, Lorcainide hydrochloride, Amiodarone, Sotalol. Anti-hyperlipidemic agents: Clofibrate, Lovastatin, Cholesteramine and Cholestipol Coagulant & Anticoagulants: Menadione, Acetomenadione, Warfarin*, Anisindione, clopidogrel Drugs used in Congestive Heart Failure: Digoxin, Digitoxin, Nesiritide, Bosentan, Tezosentan. |
| 4. | Drugs acting on Endocrine system Nomenclature, Stereochemistry and metabolism of steroids Sex hormones: Testosterone, Nandralone, Progestrones, Oestriol, Oestradiol, Oestrione, Diethyl stilbestrol. Drugs for erectile dysfunction: Sildenafil, Tadalafil. Oral contraceptives: Mifepristone, Norgestril, Levonorgestrol Corticosteroids: Cortisone, Hydrocortisone, Prednisolone, Betamethasone, Dexamethasone Thyroid and antithyroid drugs: L-Thyroxine, L-Thyronine, Propylthiouracil, Methimazole. |
| 5. | Antidiabetic agents: Local Anesthetics: SAR of Local anesthetics Benzoic Acid derivatives; Cocaine, Hexylcaine, Meprylcaine, Cyclomethycaine, Piperocaine. Amino Benzoic acid derivatives: Benzocaine*, Butamben, Procaine*, Butacaine, Propoxycaine, Tetracaine, Benoxinate. Lidocaine/Anilide derivatives: Lignocaine, Mepivacaine, Prilocaine, Etidocaine. Miscellaneous: Phenacaine, Diperodon, Dibucaine.* |
| Unit | Topic |
| 1. | Preformulation Studies- Physical & Chemical Properties BCS classification of drugs & its significant |
| 2. | Tablets: a. Introduction, ideal characteristics of tablets, classification of tablets. Excipients, Formulation of tablets, granulation methods, compression and processing problems. Equipments and tablet tooling. b. Tablet coating c. Quality control tests: In process and finished product tests Liquid orals: Formulation and manufacturing consideration of syrups and elixirs suspensions and emulsions; Filling and packaging; evaluation of liquid orals official in pharmacopoeia |
| 3. | Capsules: a. Hard gelatin capsules b. Soft gelatin capsules c. Pellet |
| 4. | Parenteral Products Ophthalmic Preparations |
| 5. | Cosmetics Pharmaceutical Aerosols Packaging Materials Science |
| Unit | Topic |
| 1. | Pharmacology of drugs acting on cardio vascular system |
| 2. | Pharmacology of drugs acting on cardio vascular system Pharmacology of drugs acting on urinary system |
| 3. | Autocoids and related drugs a. Introduction to autacoids and classification b. Histamine, 5-HT and their antagonists. c. Prostaglandins, Thromboxanes and Leukotrienes. d. Angiotensin, Bradykinin and Substance P. e. Non-steroidal anti-inflammatory agents f. Anti-gout drugs g. Antirheumatic drugs |
| 4. | Pharmacology of drugs acting on endocrine system a. Basic concepts in endocrine pharmacology. b. Anterior Pituitary hormones- analogues and their inhibitors. c. Thyroid hormones- analogues and their inhibitors. d. Hormones regulating plasma calcium level- Parathormone, Calcitonin and Vitamin-D. d. Insulin, Oral Hypoglycemic agents and glucagon. e. ACTH and corticosteroids. |
| 5. | Pharmacology of drugs acting on endocrine system a. Androgens and Anabolic steroids. b. Estrogens, progesterone and oral contraceptives. c. Drugs acting on the uterus. |
| 6. | 6. Bioassay a. Principles and applications of bioassay. b.Types of bioassay c. Bioassay of insulin, oxytocin, vasopressin, ACTH,d-tubocurarine,digitalis, histamine and 5- HT |
| Unit | Topic |
| 1. | Metabolic pathways in higher plants and their determination |
| 2. | General introduction, composition, chemistry & chemical classes, biosources, therapeutic uses and commercial applications of following secondary metabolites: Alkaloids: Vinca, Rauwolfia, Belladonna, Opium, Phenylpropanoids and Flavonoids: Lignans, Tea, Ruta Steroids, Cardiac Glycosides & Triterpenoids: Liquorice, Dioscorea, Digitalis Volatile oils: Mentha, Clove, Cinnamon, Fennel, Coriander, Tannins: Catechu, Pterocarpus Resins: Benzoin, Guggul, Ginger, Asafoetida, Myrrh, Colophony Glycosides: Senna, Aloes, Bitter Almond Iridoids, Other terpenoids & Naphthaquinones: Gentian, Artemisia, taxus, carotenoids |
| 3. | Isolation, Identification and Analysis of Phytoconstituents a) Terpenoids: Menthol, Citral, Artemisin b) Glycosides: Glycyrhetinic acid & Rutin c) Alkaloids: Atropine,Quinine,Reserpine,Caffeine d) Resins: Podophyllotoxin, Curcumin |
| 4. | Industrial production, estimation and utilization of the following phytoconstituents: Forskolin, Sennoside, Artemisinin, Diosgenin, Digoxin, Atropine, Podophyllotoxin, Caffeine, Taxol, Vincristine and Vinblastine |
| 5. | Basics of Phytochemistry Modern methods of extraction, application of latest techniques like Spectroscopy, chromatography and electrophoresis in the isolation, purification and identification of crude drugs. |
| Unit | Topic |
| 1. | Drugs and Cosmetics Act, 1940 and its rules 1945 Objectives, Definitions, Legal definitions of schedules to the Act and Rules Import of drugs Manufacture of drugs Conditions for grant of license and conditions of license for manufacture of drugs, Manufacture of drugs for test, examination and analysis, manufacture of new drug, loan license and repacking license |
| 2. | Drugs and Cosmetics Act, 1940 and its rules 1945 Detailed study of Schedule G, H, M, N, P,T,U, V, X, Y, Part XII B, Sch F & DMR (OA) Sale of Drugs Labeling & Packing of drugs Administration of the Act and Rules- DTAB, CDL, DCC, Analyst, DI, ADA |
| 3. | Pharmacy Act –1948 Medicinal and Toilet Preparation Act –1955 Narcotic Drugs and Psychotropic substances Act-1985 and Rules |
| 4. | Study of Salient Features of Drugs and Magic Remedies Act and its rules Prevention of Cruelty to animals Act-1960 National Pharmaceutical Pricing Authority |
| 5. | Pharmaceutical Legislations- Health survey and development committee, Hathi committee and Mudaliar committee Code of Pharmaceutical ethics D efinition, Pharmacist in relation to his job, trade, medical profession and his profession, Pharmacist’s oath Medical Termination of Pregnancy Act Right to Information Act Introduction to Intellectual Property Rights (IPR) |
| Unit | Topic |
| 1. | Antibiotics: Historical background, Nomenclature, Stereochemistry, Structure activity relationship, Chemical degradation classification and important products of the following classes. β-Lactam antibiotics: Penicillin, Cepholosporins, β- Lactamase inhibitors, Monobactams Aminoglycosides: Streptomycin, Neomycin, Kanamycin Tetracyclines: Tetracycline,Oxytetracycline, Chlortetracycline, Minocycline, Doxycycline |
| 2. | Antibiotics: Macrolide: Erythromycin Clarithromycin, Azithromycin. Miscellaneous: Chloramphenicol*, Clindamycin. Prodrugs: Basic concepts and application of prodrugs design. Antimalarials: Etiology of malaria. Quinolines: SAR, Quinine sulphate, Chloroquine*, Amodiaquine, Primaquine phosphate, Pamaquine*, Quinacrine hydrochloride, Mefloquine. Biguanides and dihydro triazines: Cycloguanil pamoate, Proguanil. Miscellaneous: Pyrimethamine, Artesunete, Artemether, Atovoquone |
| 3. | Anti-tubercular Agents Urinary tract anti-infective agents Quinolones Miscellaneous: Furazolidine, Nitrofurantoin*, Methanamine Antiviral agents |
| 4. | Antifungal agents Anti-protozoal Agents Anthelmintics Sulphonamides and Sulfones Sulphonamides and Sulfones |
| 5. | Introduction to Drug Design- QSAR Combinatorial Chemistry |
| Unit | Topic |
| 1. | Pharmacology of drugs acting on Respiratory system a. Anti -asthmatic drugs b. Drugs used in the management of COPD c. Expectorants and antitussives d. Nasal decongestants e. Respiratory stimulants Pharmacology of drugs acting on the Gastrointestinal Tract a. Antiulcer agents. b. Drugs for constipation and diarrhoea. c. Appetite stimulants and suppressants. d. Digestants and carminatives. e. Emetics and anti-emetics. |
| 2. | Chemotherapy a. General principles of chemotherapy. b. Sulfonamides and cotrimoxazole. c. Antibiotics- Penicillins, cephalosporins, chloramphenicol, macrolides, quinolones and fluoroquinolins, tetracycline and aminoglycosides |
| 3. | Chemotherapy a. Antitubercular agents b. Antileprotic agents c. Antifungal agents d. Antiviral drugs e.Anthelmintics f. Antimalarial drugs g. Antiamoebic agents |
| 4. | Chemotherapy l. Urinary tract infections and sexually transmitted diseases. m. Chemotherapy of malignancy Immunopharmacology a. Immunostimulants b. Immunosuppressant Protein drugs, monoclonal antibodies, target drugs to antigen, biosimilars |
| 5. | Principles of toxicology Chronopharmacology |
| Unit | Topic |
| 1. | Herbs as raw materials Biodynamic Agriculture Indian Systems of Medicine |
| 2. | Nutraceuticals Herbal-Drug and Herb-Food Interactions |
| 3. | Herbal Cosmetics Herbal excipients Herbal formulations |
| 4. | Evaluation of Drugs WHO & ICH guidelines for the assessment of herbal drugs Stability testing of herbal drugs Patenting and Regulatory requirements of natural products Regulatory Issues- ASU DTAB, ASU DCC), Schedule Z of Drugs & Cosmetics Act for ASU drugs |
| 5. | General Introduction to Herbal Industry Schedule T – Good Manufacturing Practice of Indian systems of medicine |
| Unit | Topic |
| 1. | Biopharmaceutics- Absorption & Distribution PPB |
| 2. | Biopharmaceutics- Elimination Bioavailability and Bioequivalence |
| 3. | Pharmacokinetics |
| 4. | Multicompartment models |
| 5. | Nonlinear Pharmacokinetics |
| Unit | Topic |
| 1. | Introduction to Biotechnology with reference to Pharmaceutical Sciences Enzyme Biotechnology Biosensors Protein Engineering Use of microbes in industry. Production of Enzyme principles of genetic engineering |
| 2. | a) Study of cloning vectors, restriction endonucleases and DNA ligase. b) Recombinant DNA technology. Application of genetic engineering in medicine. c) Application of r DNA technology and genetic engineering in the production of: i) Interferon ii) Vaccines- hepatitis- B iii) Hormones-Insulin. d) Brief introduction to PCR |
| 3. | Types of immunity- humoral immunity, cellular immunity a) Structure of Immunoglobulins b) Structure and Function of MHC c) Hypersensitivity reactions, Immune stimulation and Immune suppressions. d) General method of the preparation of bacterial vaccines, toxoids, viral vaccine, antitoxins, serum-immune blood derivatives and other products relative to immunity. e) Storage conditions and stability of official vaccines f) Hybridoma technology- Production, Purification and Applications g) Blood products and Plasma Substituties. |
| 4. | a) Immuno blotting techniques- ELISA, Western blotting, Southern blotting. b) Genetic organization of Eukaryotes and Prokaryotes c) Microbial genetics including transformation, transduction, conjugation, plasmids and transposons. d) Introduction to Microbial biotransformation and applications. e) Mutation: Types of mutation/mutants. |
| 5. | a) Fermentation methods and general requirements, study of media, equipments, sterilization methods, aeration process, stirring. b) Large scale production fermenter design and its various controls. c) Study of the production of – penicillins, citric acid, Vitamin B12, Glutamic acid, Griseofulvin, d) Blood Products: Collection, Processing and Storage of whole human blood, dried human plasma, plasma Substituties. |
| Unit | Topic |
| 1. | Quality Assurance and Quality Management concepts Total Quality Management (TQM) ICH Guidelines Quality by design (QbD) ISO 9000 & ISO14000 NABL accreditation |
| 2. | Organization and personnel Premises Equipments and raw materials |
| 3. | Quality Control Good Laboratory Practices |
| 4. | Complaints Document maintenance in pharmaceutical industry |
| 5. | Calibration and Validation Warehousing |
| Unit | Topic |
| 1. | UV Visible spectroscopy Fluorimetry |
| 2. | IR spectroscopy Flame Photometry |
| 3. | Introduction to chromatography • Adsorption and partition column chromatography • Thin layer chromatography- • Paper chromatography • Electrophoresis |
| 4. | Gas chromatography High performance liquid chromatography (HPLC) |
| 5. | Ion exchange chromatography Gel chromatography Affinity chromatography |
| Unit | Topic |
| 1. | Pilot plant scale up techniques |
| 2. | Technology development and transfer |
| 3. | Regulatory affairs Regulatory requirements for drug approval |
| 4. | Quality management systems |
| 5. | Indian Regulatory Requirements |
| Unit | Topic |
| 1. | a) Hospital and it’s organization b) Hospital pharmacy and its organization c) Adverse drug reaction d) Community Pharmacy |
| 2. | a) Drug distribution system in a hospital b) Hospital formulary c) Therapeutic drug monitoring d) Medication adherence e) Patient medication history interview f) Community pharmacy management |
| 3. | a) Pharmacy and therapeutic committee b) Drug information services c) Patient counselling d) Education and training program in the hospital e) Prescribed medication order and communication skills |
| 4. | a) Budget preparation and implementation b) Clinical Pharmacy c) Over the counter (OTC) sales |
| 5. | a) Drug store management and inventory control b) Investigational use of drugs c) Interpretation of Clinical Laboratory Tests |
| Unit | Topic |
| 1. | Controlled drug delivery systems Polymer |
| 2. | Microencapsulation Mucosal Drug Delivery system Implantable Drug Delivery Systems |
| 3. | Transdermal Drug Delivery Systems Gastroretentive drug delivery systems Nasopulmonary drug delivery system |
| 4. | Targeted drug Delivery |
| 5. | Ocular Drug Delivery Systems Intrauterine Drug Delivery Systems |
| Unit | Topic |
| 1. | Introduction: Statistics, Biostatistics, Frequency distribution Measures of central tendency Measures of dispersion Correlation |
| 2. | Regression Probability Parametric test: t-test, ANOVA, Least Significance difference |
| 3. | Non Parametric tests Introduction to Research Graphs Designing the methodology |
| 4. | Blocking and confounding system for Two-level factorials Regression modeling: Hypothesis testing in Simple and Multiple regressionmodels Introduction to Practical components of Industrial and Clinical Trials Problems: Statistical Analysis Using Excel, SPSS, MINITAB®, DESIGN OF EXPERIMENTS, R – Online Statistical Software’s to Industrial and Clinical trial approach |
| 5. | Design and Analysis of experiments Factorial design Response Surface methodology |
| Unit | Topic |
| 1. | Concept of health and disease Social and health education Sociology and health Hygiene and health |
| 2. | Preventive medicine |
| 3. | National health programs, its objectives, functioning and outcome of the following: HIV AND AIDS control programme, TB, Integrated disease surveillance program (IDSP), National leprosy control programme, National mental health program, National programme for prevention and control of deafness, Universal immunization programme, National programme for control of blindness, Pulse polio programme |
| 4. | National health intervention programme for mother and child, National family welfare programme, National tobacco control programme, National Malaria Prevention Program, National programme for the health care for the elderly, Social health programme; role of WHO in Indian national program |
| 5. | Community services in rural, urban and school health: Functions of PHC, Improvement in rural sanitation, national urban health mission, Health promotion and education in school. |
| Unit | Topic |
| 1. | Marketing & Pharmaceutical market |
| 2. | Product decision |
| 3. | Promotion |
| 4. | Pharmaceutical marketing channels Professional sales representative (PSR) |
| 5. | Pricing Emerging concepts in marketing Vertical & Horizontal Marketing |
| Unit | Topic |
| 1. | New Drug Discovery and development |
| 2. | Regulatory Approval Process Regulatory authorities and agencies |
| 3. | Registration of Indian drug product in overseas market |
| 4. | Clinical trials |
| 5. | Regulatory Concepts |
| Unit | Topic |
| 1. | Introduction to Pharmacovigilance Introduction to adverse drug reactions Basic terminologies used in pharmacovigilance |
| 2. | Drug and disease classification Drug dictionaries and coding in pharmacovigilance Information resources in pharmacovigilance Establishing pharmacovigilance programme |
| 3. | Vaccine safety surveillance Pharmacovigilance methods Communication in pharmacovigilance |
| 4. | Safety data generation ICH Guidelines for Pharmacovigilance |
| 5. | Pharmacogenomics of adverse drug reactions Drug safety evaluation in special population CIOMS CDSCO (India) and Pharmacovigilance |
| Unit | Topic |
| 1. | Basic tests for drugs – Pharmaceutical substances, Medicinal plants materials and dosage forms WHO guidelines for quality control of herbal drugs. Evaluation of commercial crude drugs intended for use |
| 2. | Quality assurance in herbal drug industry of cGMP, GAP, GMP and GLP WHO Guidelines on current good manufacturing Practices (cGMP) for Herbal Medicines WHO Guidelines on GACP for Medicinal Plants |
| 3. | EU and ICH guidelines for quality control of herbal drugs. Research Guidelines for Evaluating the Safety and Efficacy of Herbal Medicines |
| 4. | Stability testing of herbal medicines.Application of various chromatographic techniques in standardization of herbal products. Preparation of documents for new drug application and export registration GMP requirements and Drugs & Cosmetics Act provisions |
| 5. | Regulatory requirements for herbal medicines. WHO guidelines on safety monitoring of herbal medicines in pharmacovigilance systems Comparison of various Herbal Pharmacopoeias. Role of chemical and biological markers in standardization of herbal products |
| Unit | Topic |
| 1. | Introduction to Drug Discovery and Development Lead discovery and Analog Based Drug Design Analog Based Drug Design |
| 2. | Quantitative Structure Activity Relationship (QSAR) SAR, QSAR, 3D-QSAR, COMFA, COMSIA |
| 3. | Molecular Modeling and virtual screening techniques Virtual Screening tec Molecular docking |
| 4. | Informatics & Methods in drug design |
| 5. | Molecular Modeling |
| Unit | Topic |
| 1. | a) Cell and Molecular Biology: Definitions theory and basics and Applications. b) Cell and Molecular Biology: History and Summation. c) Properties of cells and cell membrane. d) Prokaryotic versus Eukaryotic e) Cellular Reproduction f) Chemical Foundations – an Introduction and Reactions (Types) |
| 2. | a) DNA and the Flow of Molecular Information b) DNA Functioning c) DNA and RNA d) Types of RNA e) Transcription and Translation |
| 3. | a) Proteins: Defined and Amino Acids b) Protein Structure c) Regularities in Protein Pathways d) Cellular Processes e) Positive Control and significance of Protein Synthesis |
| 4. | a) Science of Genetics b) Transgenics and Genomic Analysis c) Cell Cycle analysis d) Mitosis and Meiosis e) Cellular Activities and Checkpoints |
| 5. | a) Cell Signals: Introduction b) Receptors for Cell Signals c) Signaling Pathways: Overview d) Misregulation of Signaling Pathways e) Protein-Kinases: Functioning |
| Unit | Topic |
| 1. | Classification of cosmetic and cosmeceutical products Indian and EU regulations, Evolution of cosmeceuticals from cosmetics, cosmetics as quasi and OTC drugs Cosmetic excipients Skin Hair Oral Cavity |
| 2. | Principles of formulation and building blocks of skin care products Antiperspants & deodorants Principles of formulation and building blocks of Hair care products Principles of formulation and building blocks of oral care products: Toothpaste for bleeding gums, sensitive teeth. Teeth whitening, Mouthwash |
| 3. | Sun protection, Classification of Sunscreens and SPF. Role of herbs in cosmetics: Skin Care: Aloe and turmeric Hair care: Henna and amla. Oral care: Neem and clove Analytical cosmetics: BIS specification and analytical methods for shampoo, skincream and toothpaste |
| 4. | Principles of Cosmetic Evaluation:Principles of sebumeter, corneometer. Measurement of TEWL, Skin Color, Hair tensile strength, Hair combing properties Soaps,and syndet bars. Evolution and skin benfits. |
| 5. | Oily and dry skin, causes leading to dry skin, skin moisturisation. Basic understanding of the terms Comedogenic, dermatitis. Cosmetic problems associated with Hair and scalp: Dandruff, Hair fall causes Cosmetic problems associated with skin: blemishes, wrinkles, acne, prickly heat and body odor. Antiperspirants and Deodorants- Actives and mechanism of action |
| Unit | Topic |
| 1. | Laboratory Animals: Study of CPCSEA and OECD guidelines |
| 2. | Preclinical screening models a. Introduction: Dose selection, calculation and conversions, preparation of drug solution/suspensions, grouping of animals and importance of sham negative and positive control groups. Rationale for selection of animal species and sex for the study. b. Study of screening animal models for Diuretics, nootropics, anti-Parkinson’s,antiasthmatics, Preclinical screening models: for CNS activity- analgesic, antipyretic,anti-inflammatory, general anaesthetics, sedative and hypnotics, antipsychotic, antidepressant, antiepileptic, antiparkinsonism, alzheimer’s disease |
| 3. | Preclinical screening models: for ANS activity, sympathomimetics, sympatholytics, parasympathomimetics, parasympatholytics, skeletal muscle relaxants, drugs acting on eye, local anaethetics |
| 4. | Preclinical screening models: for CVS activity- antihypertensives, diuretics, antiarrhythmic, antidyslepidemic, anti aggregatory, coagulants, and anticoagulants Preclinical screening models for other important drugs like antiulcer, antidiabetic, anticancer and antiasthmatics. |
| 5. | Research methodology and Bio-statistics Selection of research topic, review of literature, research hypothesis and study design Pre-clinical data analysis and interpretation using Students ‘t’ test and One-way ANOVA. Graphical representation of data |
| Unit | Topic |
| 1. | Nuclear Magnetic Resonance spectroscopy Mass Spectrometry |
| 2. | Thermal Methods of Analysis X-Ray Diffraction Methods |
| 3. | Calibration and validation-ICH and USFDA guidelines Calibration of following Instruments- Electronic balance, UV-Visible spectrophotometer, IR spectrophotometer Fluorimeter, Flame Photometer, HPLC and GC |
| 4. | Radio immune assay Extraction techniques |
| 5. | Hyphenated techniques-LC-MS/MS, GC-MS/MS, HPTLC-MS. |
| Unit | Topic |
| 1. | a. Definitions of Functional foods, Nutraceuticals and Dietary supplements. Classification of Nutraceuticals, Health problems and diseases that can be prevented or cured by Nutraceuticals i.e. weight control, diabetes, cancer, heart disease, stress, osteoarthritis, hypertension etc. b. Public health nutrition, maternal and child nutrition, nutrition and ageing, nutrition education in community. c. Source, Name of marker compounds and their chemical nature, Medicinal uses and health benefits of following used as nutraceuticals/functional foods: Spirulina, Soyabean, Ginseng, Garlic, Broccoli, Gingko, Flaxseeds |
| 2. | Phytochemicals as nutraceuticals: Occurrence and characteristic features(chemical nature medicinal benefits) of following a) Carotenoids- α and β-Carotene, Lycopene, Xanthophylls, leutin b) Sulfides: Diallyl sulfides, Allyl trisulfide. c) Polyphenolics: Reservetrol d) Flavonoids- Rutin , Naringin, Quercitin, Anthocyanidins, catechins, Flavones e) Prebiotics / Probiotics.: Fructo oligosaccharides, Lacto bacillum f) Phyto estrogens : Isoflavones, daidzein, Geebustin, lignans g) Tocopherols h) Proteins, vitamins, minerals, cereal, vegetables and beverages as functional foods: oats, wheat bran, rice bran, sea foods, coffee, tea and the like |
| 3. | a) Introduction to free radicals: Free radicals, reactive oxygen species, production of free radicals in cells, damaging reactions of free radicals on lipids, proteins, Carbohydrates, nucleic acids. b) Dietary fibres and complex carbohydrates as functional food ingredients. |
| 4. | a) Free radicals in Diabetes mellitus, Inflammation, Ischemic reperfusion injury, Cancer, Atherosclerosis, Free radicals in brain metabolism and pathology, kidney damage, muscle damage. Free radicals involvement in other disorders. Free radicals theory of ageing. b) Antioxidants: Endogenous antioxidants – enzymatic and nonenzymatic antioxidant defence, Superoxide dismutase, catalase, Glutathione peroxidase, Glutathione Vitamin C, Vitamin E, α- Lipoic acid, melatonin Synthetic antioxidants: Butylated hydroxy Toluene, Butylated hydroxy Anisole. c) Functional foods for chronic disease prevention |
| 5. | a) Effect of processing, storage and interactions of various environmental factors on the potential of nutraceuticals. b) Regulatory Aspects; FSSAI, FDA, FPO, MPO, AGMARK. HACCP and GMPs on Food Safety. Adulteration of foods. c) Pharmacopoeial Specifications for dietary supplements and nutraceuticals |