In 2012, RUHS, Rajasthan was hold exam in total 8 shift for the recruitment of Pharmacists. Among these shifts, One paper of Pharmacist with answer key as follows:-
1. Lozenges are solid dosage form intended for
a) Faster action
*b) slow dissolution
c) slow disintegration
d) None of the above
Exp: Lozenges are solid preparations that are intended to dissolve or disintegrate slowly in the mouth. They contain one or more medicaments usually in a flavored, sweetened base. Lozenges are most often used for localized effects in the mouth.
Lozenges have the advantage of
1.being easy to administer to pediatric and geriatric patients.
2. having formulas that are easy to change and can be patient specific. 3.keeping the drug in contact with the oral cavity for an extended period of time. One disadvantage of using a “gummy-type” lozenge with children is they may perceive it as candy.
2. Implants are designed for
*a) Prolonged action
b) fast action
c) Increase efficiacy
d) None of the above
Exp: Implantable drug delivery devices offer several advantages over conventional oral or parenteral dosage forms. First, implantable devices allow site specific drug administration where the drug is most needed. Second, implantable devices allow for sustained release(prolonged action) of a therapeutic agent. The last and perhaps most important advantage is patient compliance.
3. International system of unit (SI) includes
*a) Metric system
b) Avoirduposis system
c) Apothecaries system
Exp: International System of Units (SI) is international decimal system of weights and measures derived from and extending the metric system of units. Adopted by the 11th General Conference on Weights and Measures in 1960, it is abbreviated SI in all languages.
4. 1.0 % w/w dextrose means
a) 1 g dextrose in 100 ml of product
*b) 1 g dextrose in 100 g product
c) 1 mole of dextrose in 100 ml of product
d) None of these
Exp: % CALCULATION
|1||% W/W (gas inliquid)||No of gm of active soln in 100 gm of product|
|2||% % %w/v(solid in liquid)||No of gm of active soln in 100 ml of product|
|3||% v/v (liquid in liquid)||No of ml of active soln in 100 ml of product|
|4||% v/w||No of ml of active soln in 100 gm of product|
5. 1 tumblerful is equivalent to
a) 200 ml
*b) 240 ml or 8 fluid ounce
c) 240 ml or 10 fluid ounce
d) 250 ml or 8 fluif ounce
|Domestic Measure||Metric system||Imperical system|
|1 drop||0.06 mL||1 minim|
|1 teaspoon full||4 mL/ 5mL in some book||1 fluid drachm|
|1 dessert spoon full||8 mL||2 fluid drachm|
|1 tablespoon full||15 mL||4 fluid drachm|
|2 tablespoon full||30 mL||1 fluid ounce|
|1 wineglassful||60 mL||2 fluid ounce|
|1 teacup full||120 mL||4 fluid ounce|
|1 tumbler full||240 mL||8 fluid ounce|
6. Micromeritics deals with study of
c) metric system of measurment
*d) small particles
Exp: Micromeritics is the science and technology of small particles. Knowledge and control of the size and the size range of particles are of significant importance in pharmacy because of the size and surface area of a particle related to the physical, chemical and pharmacologic properties of a drug.
The particle size of a drug can affect its release from dosage forms that are administered orally, parenterally, rectally and topically.
7. The extraction process, in which crude is kept in contact with menstruum is called………….?
d) none of these
Exp: Extraction: Treatment of the plant or animal tissue with solvent, whereby the medicinally active is dissolved and most of the inert matter remains undissolved.
Menstruum: solvent used for extraction is known as a menstruum
Marc: inert insoluble material that remains after the extraction
Galenicals: all preparations that are prepared by using one of the various extraction processes is known as Galenicals.
DECOCTION: In this process, the drug is boiled with water for a stated period . After boiling, the liquid is strained and water is passed through the content of the strainer to make the required volume. This process is mainly used for vegetable drugs of hard and woody nature having thermostable water soluble constituents.
MACERATION: In this process solid ingredients are placed in contact with solvent to macerate in a stoppered container with the whole of the solvent and allowed to stand for a stated period timeys (3 – 7 days) with frequent agitation, until soluble matter is dissolved. The mixture is then strained (through sieves / nets), the marc pressed and the combined liquids clarified.
8. Aqueous thermolabile solution is concentrated by a process:
a) simple distillation
b) distillation under reduced pressure
*c) evaporation under reduced pressure
d) simple evaporation
Exp: Liquid boils when vapour pressure is equal to the atmospheric pressure. If the external pressure is reduced by applying vacuum, the boiling point of liquid is lowered. Therefore, the liquid boils at a lower temperature. CLASSIFICATION OF DISTILLATION METHODS
I. Simple Distillation (Differential distillation) II.
Flash Distillation (Equilibrium distillation)
III. Vacuum distillation (distillation under reduced pressure)
IV. Molecular Distillation (Evaporation distillation or short path distillation.)
V. Fractional Distillation (Rectification)
VI. Aezotropic and extractive Distillation
VII. Steam Distillation
VIII. Destructive Distillation
IX. Compression Distillation
9. Antibiotic are preferably dried by:
a) fluidised bed drier
b) By Evaporation under reduced pressure
*c) vacuume dried
d) tray drier
10. sulphar powders are sterilised by
*a) hot air oven
Exp: Vacuum dryers-All types of heat-sensitive materials
11. Enteric coating is done when
*a) active ingradient is unstable in acid
b) active ingradient is unstable in base
c) active ingradient causes irritation in intestine
Exp: An enteric coating resists dissolution under acidic conditions, but is freely soluble at the more basic conditions of the intestinal tract. Enteric coating may be used to protect acid-labile drugs. Enteric coatings are primarily used for the purpose of:
- Maintaining the stability of APIs that are unstable when exposed to the acidic conditions of the gastric.
- Minimizing the side effects (eg, nausea, and gastric irritation and bleeding) that can occur with APIs.
- Creating opportunities for “night-time dosing” strategies, where the intent is to allow the dosage form to be consumed at bed-time, and permit effective blood levels of the API to be attained just prior to waking.
- Facilitating colonic drug delivery.
12. If average weight of tablet of 300 mg, then allowed weight variation is
a) 10 %
b) 7.5 %
*c) 5 %
|80 mg or less||± 10%||130mg or less|
|More than 80mg or Less than 250mg||± 7.5%||130mg to 324mg|
|250mg or more||± 5%||More than 324mg|
13. Shellac is used for sugar coating for
b) sub coating
Exp: Sealing is done To prevent moisture penetration in tablet core
14. Which is largest size of capsule?
|Size||Volume (mL)||m=V d (in gm)|
15. BCG vaccine contains
a) Killed bacterial suspension
*b) alive bacterial suspension
c) attenuated toxioid
16. First Indian Pharmacopoeia was published in
|Edition||Year of publication||Year of addendum/supplement released|
|IIIrd/Third||1985||1989 & 1991 Addendum|
|IVth/Fourth||1996||2000, 2002 & 2005 Addendum &|
2000 Vet supplement
|VIIth/Seventh||2014||2015 & 2016 Addendum|
|IXth/Nine||Under Preparation||tentative date December 2022|
17. Sodium bicarbonate is used as
a) Electrolyte replenisher
b) systemic alkaliser
*d) all of these
18. Aluminium hydroxide gel IP contain
a) Aluminum hydroxide
b) aluminium oxide
c) hydrated aluminium oxide
*d) Hydrated aluminium oxide with little aluminum carbonate/bicarbonate
Exp: Aluminium hydroxide Gel is an aqueous suspension of hydrated aluminium oxide together with varying quantities of basic aluminium carbonate and bicarbonate. It may contain Glycerin, Sorbitol, Sucrose or Saccharin as sweetening agents and Peppermint Oil or other suitable flavours. It may also contain suitable antimicrobial agents.
Aluminium Hydroxide Gel contains not less than 3.5 per cent and not more than 4.4 per cent w/w ofAl2O3.
19. Green vitrol is
a) copper sulphate
b) magnesium sulphate
*c) ferrous sulphate
d) sodium sulphate
Exp: Chemical formula of Green vitriol – FeSO4 and its chemical name is ferrous sulphate
20. Zinc chloride is used as
21. Lugol’s solution USP is
a) weak iodine solution
b) aqueous iodine solution
*c) strong iodine solution
|Name of Preparation||Composition: I2/KI (%w/v)||Use|
|Weak Iodine Solution IP 1966/BP||2% / 2.5 % in purified water (no alcohol)||Antiseptic|
|Aqueous Iodine Solution IP 1966 Note: Also Known as Strong Iodine Solution USP/Lugol’s Solution||5%/ 10 % in purified water (no alcohol)||Source of Iodine|
|Strong Iodine Solution IP 1966||10 %/6% in purified water 10 % & Alcohol (90%) q.s.||Antiseptic|
|Iodine tincture USP||2 % / 2.4 % NaI (Use Sod. Iodide in Place of KI)||Antiseptic|
22. Calomel is
a) magnesium chloride
*c) mercurous chloride
Exp: Calomel (Hg2Cl2), also called mercurous chloride. It has found application in certain insecticides and fungicides, however. The compound is also used in the construction of calomel electrodes for potentiometric titration (a chemical technique designed to measure the potential between two electrical conductors in a medium such as an electrolyte solution).
23. Which of these is used as preservative ?
*a) sodium benzoate
b) sodium salicylate
c) sodium metashulphite
Exp: Sodium metabisulphite is used as an antioxidant agent in many pharmaceutical formulations. Bezoic acid and its salt Sod benzoate is used as preservative.
24. Which one of these acid is used in the treatment of skin condition?
*a) Benzoic acid
b) Propionic acid
c) acetic acid
d) None of the above
Exp: Benzoic acid has a long history of use as an antifungal agent in topical therapeutic preparations such as Whitfield’s ointment (benzoic acid 6% and salicylic acid 3%). It has been used with salicylic acid as a topical antifungal agent and in the treatment of athletes foot and ringworm.
25. Which one of these is an anti-emtic agent?
a) Ammonium chloride
Exp: Dimenhydrinate is used to prevent and treat nausea, vomiting, and dizziness caused by motion sickness. Dimenhydrinate is in a class of medications called antihistamines.
26. One of these is criteria for purity of Psyllium?
a) Adsorbent power
*b) swelling factor
c) colour development
Exp: Many herbal drugs are utilized due to swelling property (those are containing an appreciable amount of constituents like mucilage, pectin or hemicelluloses), The swelling index is defined as the volume in ml taken up by the swelling of 1 g of herbal material under specified conditions. Its determination is based on the
agent as specified in the test procedure for each individual herbal material (either whole, cut or pulverized).
27. Which one of these reagent is used to indicate presence of emetine?
*a) Potassium chlorate
b) potassium bismuth iodide
c) iodine in potassium iodide solution
d) Picric acid
28. Vasaka is used as
d) cardiac tonic
29. Shark liver oil contains
*a) Vit D
c) Vit A & D
d) Vit E
30. Penicillin is discovered by
a) Robert koch
b) Robert brown
*c) Alexander flemiing
d) Paul Enhrlich
31. Which one of these is an oleogum resin?
32. Ruthenium red gives pink or red colour
a) gaur gum
33. Which one of these is a quinolone alkaloids?
34. Ma-Huang is a synonym for
35. Which one these is used in gout?
36. Beta ionine (starting material for Vit A) is prepared from terpenoid?
37. Bufadenolides are present in
38. Which one of these alkaloids does not nitrogen in the ring system?
39. Diosgenin is a
a) Alkaloid obtained from dioscorea
*b) Glycoside obtained from dioscorea
c) Protein obtained from discorea
d) None of these
40. Alanine is a
a) Essential amino acid
*b) Non essential amino acid
c) both of these
d) None of these
41. The normal level of ketone bodies in the blood is
a) 10 mg/dl
b) 40 mg/dl
c) 15 mg/dl
42. Cholesterol consists of
*a) 27 carbon atoms
b) 30 carbons
c) 14 carbons
d) 35 carbons
43. Normal value for glucose in the blood is:
a) 250 mg
b) 200 mg
c) 100-120 mg
*d) 80-120 mg
44. Mast cell responsible for release of
c) fatty Acids
d) None of above
45. The Normal erythrocyte count is
a) 3.5 millions/mm3
*b) 5.5 millions/mm3
c) 6.5 millions/mm3
d) 7.5 millions/mm3
46. Human heart is:
*a) 4 Chambered
b) 3 Chambered
c) 2 Chambered
d) 1 Chambered
47. Purkinge fibres is present in
48. Blood is supplied to the heart through
a) carotid artery
*b) coronary artery
d) Pulmonary artery
49. Polyurea is a condition characterized by
*a) Increased urine formation
b) appearance of glucose in urine
c) appearance of protein
d) all of these
50. Melatonin is secreted by:
a) Thymus gland
*c) pineal gland
d) adrenal gland
51. Female sex hormone is
52. In female ovulation take place in regular menstrual cycle on
*a) 14 days
b) 16 days
c) 20 days
d) 18 days
53. The deposition of sodium urate crystal in joints leads to disease
54. Spermatazoa are formed
a) vasa deferens
b) prostate gland
*c) seminal vesicle
55. Myopia is corrected by
a) Plane lens
*b) Concave lens
c) Convex lens
d) Cylindrical lens
56. ELISA test is used for diagnosis of
57. A protozoal disease is
58. Water bron disease is
59. Saheli, Oral contraceptives contains
d) Oestrogen & Progestrone
60. Which one of these is sexually transmitted disease?
61. An Example of Non-communicable disease is
62. Iodine deficiency disorder is
63. Vitamin C deficiency causes disease
64. HIV is a…………virus
65. Influenza spreads by
a) Faceal route
*b) Droplet infection
d) Mother to foetus
66. Simple syrup BP contains sugar
d) 50 %
67. Which one of these is anionic surfactants
*a) Sod. Lauryl sulphate
b) Glyceryl monostearate
c) Tetradeacyl trimethyl ammonium bromide
d) Sorbitan monooleate
68. Tween is a
*a) Hydrophilic surfactant
69. In Non-staining IODINE ointment, which one of these ingredient is added to bind Iodine
*a) Arachis oil
b) Yellow soft paraffin
70. Handerson Hassel equation is related to
*a) Buffer solution
b) dissolution rate
c) osmotic presssure
71. Benzalkonium chloride (eye drop preservative) is used in
*a) 0.01 %w/v
b) 0.02 %w/v
c) 1.0 %w/v
d) 0.05 %w/v
72. Which one of these paraffin wax is used in eye ointment ?
a) White soft paraffin
*b) Yellow soft paraffin
c) Hard paraffin
73. One thousand Nanogram equals to one
74. Which one of these antibiotics contain naphthacene nucleus?
75. Betamathasone & prednisonone are used in
76. Toxicity of digitalis is increased due to
a) Entry of calcium ion
*b) Depletion of potassium ion
c) Depletion of sodium ion
77. Tetracyclines are not administered with milk because
a) Toxicity is increase
b) Activity is destroyed
*c) insoluble chelates is formed
78. Most common adverse effect of NSAIS’s?
a) Liver toxicity
c) Haematological disorder
*d) Gastric ulcer
79. The licence for the manufacture of drugs are issued by
a) Drug controller of India
b) Health ministry, Govt of India
*c) State drug controller
d) Drug Inspector
80. Biological belongs to schedule
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