National Immunization Schedule (NIS) for Infants, Children and Pregnant Women

Mission Indradhanush, Pharmapedia, NIS, The Pharmapedia

India’s immunization programme, launched in 1985, is one of the largest health programmes of its kind in the world, catering to a birth cohort of 2.7 crore (27 million) children annually. The programme provides vaccination against eight life‐threatening diseases (diphtheria, whooping cough, Haemophilus influenzae type B (Hib) causing pneumonia and meningitis, tetanus, polio, tuberculosis, measles and hepatitis B) in the entire country.

In addition, vaccination against Japanese Encephalitis (JE) is provided in the selected endemic districts/states of the country. Recently, rotavirus vaccine (RVV) has been introduced in the four selected states (Andhra Pradesh, Haryana, Himachal Pradesh and odisha).

VaccineWhen to giveDoseRouteSite
For Pregnant Women
TT-1Early in pregnancy0.5 mlIntra-muscularUpper Arm
TT-24 weeks after TT-1*0.5 mlIntra-muscularUpper Arm
TT- BoosterIf received 2 TT doses in a pregnancy within the last 3 yrs*0.5 mlIntra-muscularUpper Arm
For Infants
BCGAt birth or as early as possible till one year of age0.1ml (0.05ml until 1 month age)Intra-dermalLeft Upper Arm
Hepatitis B – Birth doseAt birth or as early as possible within 24 hours0.5 mlIntra-muscularAntero-lateral side of mid-thigh
OPV-0At birth or as early as possible within the first 15 days2 dropsOralOral
OPV 1, 2 & 3At 6 weeks, 10 weeks & 14 weeks (OPV can be given till 5 years of age)2 dropsOralOral
Pentavalent 1, 2 & 3At 6 weeks, 10 weeks & 14 weeks (can be given till one year of age)0.5 mlIntra-muscularAntero-lateral side of mid-thigh
Rotavirus#At 6 weeks, 10 weeks & 14 weeks (can be given till one year of age)5 dropsOralOral
IPVTwo fractional dose at 6 and 14 weeks of age0.1 mlIntra dermal two fractional doseIntra-dermal: Right upper arm
Measles /MR 1st Dose$9 completed months-12 months. (can be given till 5 years of age)0.5 mlSub-cutaneousRight upper Arm
JE – 1**9 completed months-12 months.0.5 mlSub-cutaneousLeft upper Arm
Vitamin A (1st dose)At 9 completed months with measles- Rubella1 ml ( 1 lakh IU)OralOral
For Children
DPT booster-116-24 months0.5 mlIntra-muscularAntero-lateral side of mid-thigh
Measles/ MR 2nd dose $16-24 months0.5 mlSub-cutaneousRight upper Arm
OPV Booster16-24 months2 dropsOralOral
JE216-24 months0.5 mlSub-cutaneousLeft Upper Arm
Vitamin A*** (2nd to 9th dose)16-18 months. Then one dose every 6 months up to the age of 5 years.2 ml (2 lakh IU)OralOral
DPT Booster-25-6 years0.5 ml.Intra-muscularUpper Arm
TT10 years & 16 years0.5 mlIntra-muscularUpper Arm
National Immunization Schedule

Note: DPT 1, 2 & 3 are replaced by Pentavalent 1, 2 & 3. Hepatitis B 1, 2 & 3 are replaced by Pentavalent 1, 2 & 3

Maximum age for vaccination

VaccineWhen to give/Due ageMax Age
For Pregnant Women
TT-1Early in pregnancyGive as early as
possible in
pregnancy
TT-24 weeks after TT-1*
TT- BoosterIf received 2 TT doses in a pregnancy within the last 3 yrs*
For Infants
BCGAt birth or as early as possible till one year of agetill one year
of age
Hepatitis B – Birth doseAt birth or as early as possible within 24 hourswithin 24
hours
OPV-0At birth or as early as possible within the first 15 dayswithin the
first 15 days
OPV 1, 2 & 3At 6 weeks, 10 weeks & 14 weeks (OPV can be given till 5 years of age)till 5 years of
age
Pentavalent 1, 2 & 3At 6 weeks, 10 weeks & 14 weeks (can be given till one year of age)1 year of age
Rotavirus#At 6 weeks, 10 weeks & 14 weeks (can be given till one year of age)1 year of age
IPVTwo fractional dose at 6 and 14 weeks of age1 year of age
Measles /MR 1st Dose$9 completed months-12 months. (can be given till 5 years of age)5 years of age
JE – 1**9 completed months-12 months.15 years of
age
Vitamin A (1st dose)At 9 completed months with measles- Rubella5 years of age
For Children
DPT booster-116-24 months7 years of age
Measles/ MR 2nd dose $16-24 months5 years of age
OPV Booster16-24 months5 Years
JE216-24 monthstill 15 years of
age
Vitamin A*** (2nd to 9th dose)16-18 months. Then one dose every 6 months up to the age of 5 years.Up to the age
of 5 years
DPT Booster-25-6 years7 years of age
TT10 years & 16 years16 years
National Immunization Schedule

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