GPAT Exam Paper 2023 with Answer Key

Q.101) In context to voltammetry, which of the following statement is false

[a] Technique can be used to analyse organic compounds containing carbonyl groups

*[b] Organic solvents cannot be used as aqueous organic mixture in this technique

[c] Immuno sensors are available in voltammetry

[d] Triangular waveform is used for excitation of solution in cyclic voltammetry

Q.102) Which of the following Urinary Tract Anti-Infective agents requires an acidic pH of urine for optimum action

[a] Gentamicin

[b] Erythromycin

*[c] Carbenicillin

[d] Streptomycin

Q.103) The molecule having zero dipole moment is

*[a] BF3

[b] HF

[c] NH3

[d] CH3CI

Q.104) As the solution of a strong electrolyte is diluted, the following phenomenon is observed

*[a] The specific conductance decreases and equivalent conductance increases

[b] The specific conductance increases and equivalent conductance decreases

[c] Both specific conductance and equivalent conductance increase

[d] Both specific conductance and equivalent conductance decrease

Q.105) Alzheimer’s disease is mainly because of the neurodegeneration of the following part of the brain

[a] Hypothalamus

[b] Midbrain

*[c] Hippocampus

[d] Cerebellum

Q.106) Choose the correct and the major product formed in the above-given reaction from the choices listed below

[a] 2-Pentene

*[b] 2-Methyl-2-butene

[c] 1-Pentene

[d] 1-Methyl-2-butene

Q.107) Which of the following molecular properties can be determined by Thermogravimetric Analysis

[a] Solubility

*[b] Hygroscopicity

[c] Colour stability

[d] Hydrolysis

Q.108) Which of the following levels of IVIVC is represented by “the relationship between one dissolution time point (e.g. t 50%) and one mean pharmacokinetic parameter, such as AUC, Tmax or Cmax

[a] Level A

[b] Level B

*[c] Level C

[d] Level D

Q.109) Which of the following metabolite is used to inactivate the vasicotoxic metabolites leading to hemorrhagic cystitis by alkylating agents used in the treatment of cancer

[a] Acroline

[b] Aldophosphamide

[c] Cyclophosphamide

*[d] Mesna

Q.110) The difference in velocity between two planes of liquids separated/infinitesimal distance is called

*[a] Rate of shear

[b] Rate of flow

[c] Rate of force

[d] Shearing stress

Q.111) Which one is not the characteristics of the Hexose Monophosphate Pathway

[a] It produces CO2

*[b] It requires ATP for phosphorylation

[c] It is controlled by inhibition of glucose-6 phosphate dehydrogenase by NADPH

[d] It produces ribose-5-phosphate

Q.112) Which of the following drugs has an apparent volume of distribution approximately 6500 litres

[a] Amoxicillin

[b] Ibuprofen

*[c] Chloroquine

[d] Diazepam

Q.113) Which of the following hyperlipidemic drugs act via a GPCR

*[a] Nicotinic acid

[b] Fenofibrate

[c] Atorvastatin

[d] Ezetimibe

Q.114) Under which of the following conditions in-vitro-in-vivo correlation for a drug fails

*[a] When the drug is highly soluble

[b] When the drug’s absorption takes place by a complex process

[c] When the dissolution medium is adequately simulated

[d] When the drug is highly permeable but poorly soluble

Q.115) Which of the following pharmaceutical solvent has the highest dielectric constant, at 25 degree C

*[a] Glycerin

[b] Ethanol

[c] Acetone

[d] Phenol

Q.116) Which of the following is true for bone tissue cell differentiation and maturation

*[a] Osteogenic →  Osteoblasts → Osteocytes

[b] Osteogenic → Osteoblasts → Osteoclasts

[c] Osteocytes → Osteogenic → Osteoblasts

[d] Osteoclasts → Osteoblasts → Osteocytes

Q.117) Which of the following drug can produce mydriasis without Cycloplegia

[a] Atropine

[b] Tropicamide

[c] Homatropine

*[d] Ephedrine

Q.118) The law of relative lowering of vapour pressure was given by

*[a] Raoult

[b] Ostwald

[c] Henry

[d] Van’t Hoff

Q.119) Which one of the following compound is a precursor for the biosynthesis of cholesterol

[a] Progesterone

*[b] Lanosterol

[c] Cholic acid

[d] Coprostanol

Q.120) Basic dyes are used in microbiological staining. Which of the following statement is wrong about mechanism of staining

[a] The positive ions on the surface of bacteria form a colored complex with the dye

[b] Ionic exchange between the negative charge on the bacteria and positive charge of dye takes place

[c] Ionic exchange between the positive charge on the bacteria and negative charge of dye takes place

*[d] The neutral charge on the surface of bacteria forms a colored complex with the basic dye

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