Evaluation of Gels | Pharmaceutics

Pharmaceutical, Gel, Evaluation, Pharmacy notes, B.Pharm, D.Pharm, Pharmapedia, the pharmapedia, ThePharmapedia,

1. Appearance

  • The medicated Gels can be examined physically for appearance like clarity, colour and presence of any particle.

2. Skin irritation

  • Skin Irritation is determined by applying the gel on the skin of healthy volunteers.
    • No irritation: 0
    • Slight irritation: 1
    • Irritation: 2

3. pH

  • pH of Gels can be measured using digital pH meter.
  • Standard pH of gel is 5 to 5.5.

4. Viscosity

  • Viscosity was determined using Brookefield viscometer.

5. Drug content

  • Determined by appropriate spectrophotometrically like uvspectrophotometer.

6. Spreadability

  • Spreadability is measured by spreading 0.5 g Gel on a circle of 2 cm diameter on a glass plate. Then a second glass plate is placed. 1/2 kg weight placed on the upper glass plate for 5 minutes.
  • Finally diameter of circle spreading is measured.

S = ML/T

SPREADIBILITY


M= weight of an upper side
L= length of circle/ diameter
T= time in minutes

S=Spreadibility

7. Stability

  • Also known as shipping test.
  • It is performed to determine stability of Gel at various temperatures and RH (Relative humidity). Read more – stability Test

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