DI GPSC Exam Paper 2010-Gujrat
1. Patients suffering from multidrug resistant tuberculosis can be treated with all of the following drugs except:
a. Tobramycin
b. Amikacin
c. Ciprofloxacin
d. Clarithromycin
2. Which of the following anti malarial drug is safe during pregnancy?
a. Amodiaquine
b. Proguanil
c. Primaquine
d. Chloroquine
3. Mechanism of action of Ketoconazole is
a. Inhibits ergo sterol synthesis
b. Inhibits DNA gyrase
c. Inhibits dihydropteroatesynthetase
d. Induces translation misreadings
4. Monitoring plasma drug concentration is useful while using
a. Antihypertensive drugs
b. Levodopa
c. Lithium carbonate
d. MAO inhibitors
5. Codeine differs in structure from morphine by
a. N-methyl group
b. Acetyl group at Ci and C6
c. -OCzHs group
d. -OCH3 group
6. Sanguiamarine belongs to the subgroup of
a. Morphinans
b. Benzyl isoquinolines
c. Phthalideisoquinolines
d. Benzophenanthrenes
7. Dovers powder used as a diaphoretic contains
a. lpecac and Opium
b. Senna and Cinchona
c. Opium and cinchona
d. All of the above
8. ……………. is the dimmer of flavones and flavonones.
a. Chalcones
b. Aurones
c. Biflavanoids
d. Dihydroflavones
9. The wavelength source in NMR spectrometer is
a. Goniometer
b. Radiofrequency oscillator
c. High voltage generator
d. Klystron oscillator
10. Morphine does not cause
a. Constriction of the pupil
b. CNS depression
c. Respiratory depression
d. Diarrhoea
11. o,m,p-isomers can be differentiated on the basis of
a. Chemical Shift
b. Coupling constant
c. Extinction coefficient
d. Dipole moment
12. Isotopes differ in
a. The number of protons
b. The valency number
c. The chemical activity
d. The number of neutrons
13. Purity of water for injection is checked by
a. Potential testing
b. Pyrogen testing
c. Conductivity testing
d. pH Testing
14. The phosphate of a metal has the formula MHP04.The formula of its Bromide would be
a. MBr
b. MBrz
c. MBr3
d. MBr4
15. Geometrical isomerism is possible in case of
a. 2-Pentene
b. Pentane
c. Propene
d. Ethene
16. The IUPAC name of the compound having the formula(CH3)2CHCH2C1.
a. 2-methyl-3-chloropropane
b. l-chloro-3-methyl butane
c. 1-chloropentane
d. 2-methyl-4-chlorobutane
17. In mammals, the major fat in adipose tissue is
a. Triglyceride
b. Cholesterol
c. Sphingolipids
d. Phospholipid
18. Ferritinis
a. Co enzyme
b. The stored form of iron
c. Non-protein moiety
d. ls enzyme
19. Active form of Vitamin D in man is
a. Cholecalciferol
b. Calcifediol
c. Calciferol
d. Calcitriol
20. Many drugs are chiral. In a synthesis of chiral drug molecules in symmetric environment,
a. Always one enantiomer is obtained
b. Always both enantiomers are in equal amounts
c. Always both enantiomers are in unequal amounts
d. None of the above
21. Homatropine is a
a. Tropine ester of amino acetic acid
b. Tropine ester of mendelic acid
c. Tropine methyl bromide ester of mendelic acid
d. Tropine ester of amino formic acid
22. List of the drugs whose import, manufacture and sale, labelling and packaging are governed by special provisions are included in schedule
a. x
b. K
c. H
d. G
23. Dose dumping may be a general problem in the formulation of
a. Soft gelatin capsules
b. Suppositories
c. Modified release drug products
d. None of the above
24. Which of the following is useful as diluent, binder, disintegrating agent as well as lubricant in tablet formulations?
a. Starch
b. Tragacanth
c. Sucrose
d. None of the above
25. Capping in tablets mainly occurs due to
a. Less upper punch pressure
b. Poor flowability of granules
c. Proper formulation design
d. Entrapment of air in tablet during compression
26. The franz diffusion cell which is used for the evaluation of transdermal drug delivery systems consists of
a. 1 chamber
b. 2 chamber
c. 3 chamber
d. None of the above
27. Quick breaking aerosols are applicable
a. Orally
b. Parenterally
c. Topical
d. Ophthalmically
28. In an osmotic drug delivery system, the drug is released through
a. Polymeric matrix
b. Delivery orifice
c. Plastic matrix
d. None of the above
29. Parenteral product must be
a. Packed in bottle
b. Sterilized
c. Free from viable/living organism
d. Pyrogenic
30. Water attack test is generally performed for
a. USP type I glass
b. USP type II glass
c. USP type III glass
d. All of above
31. Silicone based adhesives used in transdermal drug delivery possess
a. Excellent chemical stability
b. Low toxicity
c. Skin compatibility
d. All of the above
32. The plasma-drug concentration in meg/ml data obtained after the oral administration of 50 mg of a drug are 5.5 in 1 h,9.2 in 2 h,14.9 in 3 h,10.3 in 4h,7.1 in 5 h, and 2.2 in 6h.The AUC for the blood data will be
a. 45.35 meg/ml, h
b. 55.35 meg/ml, h
c. 50.35 meg/ml, h
d. 46.35 meg/ml, h
33. Schleuniger tester is used for the tablets to measure
a. Roughness
b. Hardness
c. Dissolution
d. Friability
34. Creatinine clearance is used as a measurement of
a. Passive renal absorption
b. Glomerular filtration rate
c. Drug metabolism rate
d. Renal excretion rate
35. The drug of choice in prolonged febrile convulsions is
a. Carbamazepine
b. Diazepam
c. Phonation
d. Paracetamol
36. Which one of the following antihistamines is least to cause sedation?
a. Diphenhydramine
b. Desloratadine
c. Chlorphenamine
d. Alimemazine
37. The following electrolyte disturbance causes digitalis toxicity
a. Hypocalcemia
b. Hypernatremia
c. Hypokalemia
d. Hyperkalemia
38. Which of the following antifungal drug causes drug-drug interaction as it has a greater propensity to inhibit mammalian cytochrome P 450 enzymes
a. Itraconazole
b. Fluconazole
c. Ketoconazole
d. Miconazole
39. Select the incorrect statement from the following:
a. Half life of atropine is 4 hours
b. Acetylcholine and atropine show irreversible antagonism
c. Atropine is a central nervous system stimulant
d. Atropine produces cycloplegia
40. The anti-inflammatory agent which selectively inhibits COX-H gene expression is
a. Rofecoxib
b. Dexamethasone
c. Ibuprofen
d. Nimesulide
41. Vascular endothelial growth factor and Fibroblast growth factor are similar in all respects except:
a. Both are potent endothelial cell mitogens
b. Both are localized on cells and extracellular matrix, particularly in the lungs
c. Both stimulate endothelial cell synthesis of pro-teases including plasminogen activator and Metalloptreinases
d. Both lack a Secretory signal sequence
42. Ma-Huang is the synonym of which drug?
a. Belladonna
b. Opium
c. Ephedra
d. Ipecac
43. Coffee Arabica contains_caffeine,
a. 10%
b. 1-2%
c. 20%
d. 0.5%
44. Anaferine and Anahygrine alkaloids are present in
a. Hyocyomu
b. Ashwagandha
c. Vinca
d. Vasaka
45. Constituents which exhibit steroidal type of action are found in
a. Dioscorea
b. Senega
c. Ashwagandha
d. Ajuga parviflora
46. Select the synonyms of aconite root,
a. Vachang
b. Monkshood
c. All of the above
d. None of the above
47. Diosgenineis
a. An alkaloid obtained from dioscorea
b. A carbohydrate from dioscorea
c. A glycoside from dioscorea
d. None of the above
48. Glandular hair having a unicellular or occasionally a short unicellular padiel with a unicellular bicellular terminal gland is characteristic of
a. Senna leaves
b. Belladona Leaves
c. Datura Stramonium leaves
d. Digitalis purpurea leaves
49. The drug which is bacterial to all three pools extracellular, intracellular, and necrotic caseum of turbercle bacilli is
a. Isoniazide
b. Ethambutol
c. Pyrazinamide
d. Rifampin
50. The most useful class of drugs in the long term treatment of hypertension is
a. Thiazide diuretics
b. Osmotic diuretics
c. Mercurial diuretics
d. Pentazocin
51. Which of the following drug is not acting on opioid k (Kappa) receptor?
a. Buprenorphine
b. Butorphanol
c. Nalbuphine
d. Pentazocine
52. Which of the following crosses the blood-brain barrier?
a. GABA
b. Propranolol
c. Suxamethonium
d. Dopamine
53. Most of the drugs are absorbed in the body by means of
a. Active transport
b. Passive transport
c. Ion-pair transport
d. Facilitated diffusion
54. Insulin stimulates glucose transport by promoting the translocation of
a. GLUT 4
b. GLUT 2 and GLUT4
c. GLUT land GLUT4
d. GLUT2
55. Ptylin is secreted by
a. Pancreas
b. Lachrymeal gland
c. Parotid gland
d. None of the above
56. Which of the following is COX-2 inhibitor?
a. Aspirin
b. Ibuprofen
c. Diclofenac sodium
d. Celecoxib
57. Which following adrenergic agonist does not contain 3,4-dihydroxy nucleus?
a. Ephedrine
b. Albuterol
c. Phenylpropanolamine
d. Terbutaline
58. …………… is selective ACE inhibitor
a. Atenolol
b. Ramipril
c. Losartan
d. Nifedipine
59. Which of the following is third generation fluoroqui-nokme?
a. Lomefloxacin
b. Ciprofloxacin
c. Gemifloxacin
d. Gatifloxacin
60. QSAR stands’ for
a. Qualitative structure activity relationship
b. Quantitative structure action relationship
c. Quantitative structure activity relationship
d. Qualitative structure activity relativity
61. Which of the following is a cholesterol absorption inhibitor?
a. Atorvastatin
b. Ezetimibe
c. Fenofibrate
d. Nicotinic acid
62. One of the following is HIV NNRT inhibitor:
a. Lopinavir
b. Efavirenz
c. Zidovudine
d. Acyclovir
63. Which of the following is not a sulpha drug?
a. Captopril
b. Enalapril
c. Fosinopril
d. Losartan
64. ____is potassium sparing diuretic.
a. Furosemide
b. Eplerenone
c. Ethacrynic acid
d. Hydrochlorthiazide
65. Which of the following beta blocker produces nitric oxide?
a. Atenolol
b. Pindolol
c. Metoprolol
d. Betaxolol
66. As per ICH guideline, lower limit of quantification is S/N ratio.
a. 2
b. 3
c. 5
d. 10
67. 0.9%w/v NaCl solution is equal to
a. 2 meq per 10ml
b. 1.53 meq per 10 ml
c. 20 meq per 10ml
d. None of the above
68. RP-HPLC involves
a. Less polar mobile phase less than stationary phase
b. Less polar stationary phase less than mobile phase
c. Reverse osmosis
d. Forward osmosis
69. The statement “Store in cool place” as per IP means
a. Store at room temperature
b. Store between 2C to 8
C
c. Store at any temperature between 8C to 25
C
d. Store at 8C
70. A retardant material that forms a hydrophilic matrix in the formulation of matrix tablet is
a. H.P.M.C.
b. C.A.P.
c. Polyethylene
d. Carnuba wax
71. Tetrabromofluorecin produces _____ stain during folic apptication on the lips.
a. Bluish Red
b. Reddish blue
c. Orange Yellowish,
d. Yellowish blue
72. If the expiry date of tablet is not mentioned on the tablet, means that expiry time in years is
a. 2year
b. 3 years
c. 4 years
d. 5 years
73. Which order of the reaction is followed by photo decomposition of the drug?
a. First
b. Pseudo first
c. Second
d. Zero
74. Glass used for the preparation of vials ampoules and transfusion bottles is
a. Type-II soda lime glass
b. Type-III soda lime glass
c. Borosilicate glass
d. Neutral glass
75. Which tissue has the greatest capacity of biotransformation of drugs
a. Brain
b. Kidney
c. Liver
d. Lung
76. Clinical trials are performed on
a. Animals
b. Humans
c. Both
d. None of the above
77. The loading dose(DL)of a drug is usually based on the
a. Total body clearance(CL.)of the drug
b. Percentage of drug bound to plasma proteins
c. Fraction of drug excreted unchanged in the urine
d. Apparent volume of distribution(Vd)and desired drug concentration in plasma
78. License for wholesale of drug specified in Schedule C and C, are issued in the forms
a. 20A
b. 20B
c. 21B
d. 22A
79. On cancellation of manufacturing license, the loan license is
a. Cancelled
b. Suspended
c. Temporary suspended
d. None of the above
80. Drug retail sale licenses are issued by
a. Drug controller of India
b. Union health minister
c. Drug controller authority of the states
d. Director of Health services
81. The record for the drugs having date of expiry should be preserved for a period of at least
a. 5years
b. 2 years
c. 1 year
d. 3 years
82. Which type of trichome is present in ashwagandha?
a. Branched
b. Lignified
c. Glandular
d. None of the above
83. Chotta chand is synonym for
a. Rauwolfia Serpentina
b. Rauwolfia Densiflora
c. Rauwolfia Perakensis
d. Rauwolfia Tetraphylla
84. How can we detect the rhizomes from the root of the Rauwolfia?
a. By the presence of small central pith
b. By the-absence of small central pith
c. By the presence of vascular bundle
d. None of the above
85. Ergotoxine group of alkaloid is/are mixture of
1.Ergocristine
2. Ergocornine
3. Ergocryptine
4. Ergometine
a. 1, 2 and 3
b. 2, 3 and 4
c. 1, 2 and 4
d. None of the above
86. A disease called ‘stripe canker’ is connected with which of the following drug?
a. Nux vomica
b. Rauwolfia
c. Ashwagandha
d. Cinchona
87. If cyanocobalamine is imported under the name of tetracycline, it will be called adulterated drug
a. Spurious drug
b. Misbranded drug
c. Substitute drug
d. None of the above
88. Ergot powder gives blue colour with
a. p-dimethylamino benzaldehyde
b. o-dimethylamino benzaldehyde
c. All of the above
d. None of the above
89. Neomycin is obtained from
a. E. Coli
b. B. Subtilis
c. S. aeruginosa
d. S. fradiae
90. Biological and biotechnological products are listed in Schedule
a. A
b. B
c. C and C1
d. X
91. Carbopols are polymerized from
a. Methacrylate esters
b. Acrylic acid
c. Ethylene glycols
d. Bis-phenol + phosgene
92. Hard gelatin capsule of size 3 will accommodate approximately —— volume in ml.
a. 1
b. 2
c. 3
d. 75
93. The international name for small box vaccine is
a. BC
b. DTP
c. Viriola
d. Vibrio
94. Blood flow through a capillary is described by the equation known as
a. Lengmuir
b. Noyes Whitney
c. Stokes
d. Hilderbrand
95. Compact size and low weight mass instrument is
a. EI-TOF
b. Maldi-Quadrupole
c. Maldi-TOF
d. Lon trap
96. In polarography current must be blocked,
a. Residual
b. Migration
c. Diffusion
d. None
97. IP 2007 and USP 2006 use nitrite titration for those drugs having
a. phenolic structure
b. 1 ° Aromatic amine
c. Unsaturation
d. 3 ° Nitrogen
98. A non-hazardous substitute for RIA is
a. Flame photometry
b. HPLC
c. Fluorometry
d. GCMS
99. LCMS is widely used in
a. Multielectrolyte assay
b. Drug metabolite study
c. Complex mixture assay
d. Paint biosynthesis
100. Pantothenic acid is a part of
a. Renin
b. Carboxypeptidase
c. Co-enzyme A
d. NAD
