61. All of the following statements about the extrapyramidal effect of neuroleptics are correct except
a. They are caused by blockage of dopamine receptor
b. They are less likely to be produce by clozapine than by fluphenazine
c. Neuroleptics may cause tardive dyskinesia
d. Haloperiodol does not cause extrapyramidal disturbance
62. In tablet manufacturing process, Mottling refers to…
a. Unequal distribution of color on tablet surface
b. Tablet breaks into two layer
c. Development of cracks in tablet
d. Formation of wings
63. Sterility test for molds and yeasts should be conducted with
a. Thioglycollate medium
b. Agar plates
c. Honey media
d. Glucose broth
64. The oral prolonged drug delivery system release depend upon physical processes EXCEPT
a. Permeation of the matrix by water
b. Diffusion of drug from matrix
c. Erosion of matrix
d. Metabolism of drug
65. Microencapsulation achieved by
a. Membrane permeability
b. Co-acervation phase separation
c. Dissolution of coating
d. Sugar Coating
66. Sidenafil is used for treatment of one of the following disorder
a. Systolic Hypertension
b. Unstable angina
c. Pulmonary Hypertension
d. Hypertension due to eclampsia
67. Cardiac glycosides have the following configuration in the aglycone part of the
steroid nucleus:
a. 5a, 14 a
b. 5a, 14β
c. 5β, 14a
d. 5β, 14β
68. The film type transdermal drug delivery system (TDDS) could have a polymer EXCEPT
a. Ethylcellulose
b. Polyvinyl alcohol
c. Poly ethylene glycol
d. Glass substrate
69. The size of small Unilamellar Vesicle (SUV) Liposomal spherical structure usually
between…,
a. 20 nm – 100 nm
b. 100 nm – 400 nm
c. 1 μm and larger
d. 200 nm – 3 μm
70. Removal and killing of all microorganism is known as
a. Destruction
b. Sterilization
c. Pasteurization
d. Removal
71. The efficiency of moist heat sterilization is tested with
a. Clostridium botulinum
b. Spores of aerobic bacteria
c. Spores of bacillus stearothermophilus
d. Vegetative cells of Bacillus Stearothermophilus
72. Which is called as cold sterilization?
a. Autoclave
b. Gamma rays
c. Infrared rays
d. UV rays
73. Schedule H of the Drug and Cosmetic Act, 1945 contains
a. Antibiotics and Antihistaminic
b. Vaccine and sera
c. Biological and special product
d. Drugs to be sold only on the prescription of a registered medical practioner
74. Narcotic drug and Psychotropic Substance Act was passed in the year
a. 1945
b. 1950
c. 1985
d. 1986
75. The Pharmacy Act was passed in the year
a. 1945
b. 1948
c. 1954
d. 1985
76. The Essential Commodities Act is comes under which department?
a. Department of External affairs
b. Department of Consumer affairs
c. Department of finance
d. Export import
77. What is the full name of IPDMS?
a. Indian Pharmaceutical Development monograph system
b. International pharmaceutical development management system
c. Integrated Pharmaceutical Database management system
d. Institute of Pharmaceutical development management system
78. Which route of drug administration is most likely to lead to the first pass effect?
a. Sublingual
b. Oral
c. Intravenous
d. Intramuscular
79. What is characteristic of the intramuscular route of drug administration?
a. Only water solution can be injected
b. Oily solution can be injected
c. Opportunity of hypertonic solution injections
d. The action develops slower, than at oral administration
80. When Bioequivalence studies are necessary
a. When the new drug is a gas
b. When new drug are to be administered parenterally as aqueous solutions
and contain the same active substance in the same concentration and the same
excipient.
c. When the new drug is a powder for reconstitution as a solution
d. Fixed-dose combination products with systemic action
