41. If an agonist can produce maximal effects and has high efficacy it’s called:
a. Partial agonist
b. Antagonist
c. Agonist – Antagonist
d. Full agonist
42. Which is not the use of ergot?
a. Oxytocin
b. Prevent bb
c. Migraine
d. Laxative
43. Indicate the local anaesthetic, which is ester of para amino benzoic acid:
a. Procaine
b. Cocaine
c. Lidocaine
d. Mepivacaine
44. Which antiepileptic drug acts by inhibiting central effects of excitatory amino acids?
a. Diazepam
b. Lamotrigine
c. Ethosuximide
d. Topiramate
45. Which consideration is not true for phenytoin?
a. It inhibits calcium channel
b. Structurally related to the barbiturates
c. Effective against partial seizure
d. Effective against generalized seizure
46. Which of the following insulin preparation has the longest duration of action?
a. Semilente
b. Protamine zinc
c. Lente
d. Isophane
47. Anti-microbial action of penicillin is due to its effect on
a. Protein synthesis
b. Cell membrane
c. Cell wall synthesis
d. DNA synthesis
48. Aminoglycoside inhibit bacterial protein synthesis by binding to
a. 30s ribosomal particles
b. Peptidoglycans in cell wall
c. DNA
d. m-RNA
49. The drug which is potent vanilloid receptor agonist that selectively stimulates
nociceptive nerve endings
a. Icatibant
b. Papaverine
c. Capsaicin
d. Methadone
50. Which enzyme is a constitutive enzyme in most tissue and having a house keeping role in the body?
a. COX – 1
b. COX – 2
c. 5 – HT
d. 15 – HT
51. Which anti-inflammatory drug having most common side effect of skin reaction?
a. Aspirin
b. Acetaminophen
c. Ibuprofen
d. Mefenamic acid
52. Match the antiasthamatic drug with their mechanism of action
P. Salbutamol 1. Bronchodilator
Q. Oxitropium 2. Muscarinic receptor agonist
R. Zafirlukast 3. The cysteinyl – leukotriene receptor antagonist
S. Loratidine 4. Histamine H1 – receptor agonist
a. P-1, Q-2, R-3, S-4
b. P-2, Q-3, R-4, S-1
c. P-3, Q-4, R-1, S-2
d. P-4, Q-1, R-2, S-3
53. Which drug is non analgesic opiate and used as a cough suppressant?
a. Dextromethorphan
b. Cromoglicate
c. Pholcodine
d. Glucocorticoids
54. Antileprotic action of Dapsone is due to mainly effect on
a. Inhibition of folate synthesis
b. Calcium channel blocker
c. Phagocytosis
d. DNA synthesis
55. Which of the following statement is not true for Isoniazide
a. It inhibit synthesis of mycolic acid
b. Metabolism involves Acetylation
c. Used to prevent bronchospasm
d. It may cuase haemolytic anaemia
56. The cefuroxime drug comes under
a. 1st Generation compound
b. 2nd Generation compound
c. 3rd Generation compound
d. 4th Generation compound
57. Which antimalarial drug is not a blood schizonticidal drug?
a. Halofantrine
b. Mefloquine
c. Primaquine
d. Chloroquine
58. The absorption of water is under the control of ______________ hormone.
a. vasopressin
b. Aldosterone
c. Androgen
d. glucocorticoid
59. Match the mechanism of action of respective vasodilator drug
P. Calcium antagonist 1. Enalkiren
Q. Activate Potassium channel 2. Nitroprusside
R. Act via cyclic nucleotides 3. Minoxidil
S. Renin inhibitor 4. Verapamil
a. P-4, Q-1, R-2, S-3
b. P-2, Q-3, R-4, S-1
c. P-4, Q-3, R-2, S-1
d. P-1, Q-2, R-3, S-4
60. Amoebiasis is an infection of
a. E. Coli
b. Entamoeba histolytica
c. Leishmania
d. Trypanosoma gambiense
