CONCEPT OF DISEASE (Epidemiologic triad & Rothman’s Causal Pies)

A. Disease:

Any harmful deviation from the normal functional/ structural state of an organism/ person.  The normal state of the organism (human/plant) represents the condition of physiological balance (homeostasis).

B. Epidemiologic triad

The traditional model for infectious disease:- Interaction of these three factors is necessary to initiate the disease process (agent, host & environment). These three factors are referred to as an epidemiological triad.

Epidemiologic triad, Concept of disease, Pharmapedia, ThePharmapedia, Pharmacy Notes, HECP
Epidemiologic triad

C. Rothman’s Causal Pies: 

The agent-host-environment model did not work well for many non-infectious diseases, Causal Pies was proposed by Rothman.

 Rothman’s Causal Pies chart, Pharmapedia, HECP, Pharmacy Notes
 Rothman’s Causal Pies

D. Natural history of disease:

A study of the evolution of the disease from the earliest stage (pre pathogenesis)  to its termination (recovery,  disability or death).

Natural history of the disease is used for the prevention of disease

Natural history of the disease is established by:

i.     Cohort studies

ii.     Cross-sectional studies

iii.     Retrospective studies

Phase of the natural history of disease- 2 phases

i.     Prepathogenesis

(process in environment,  agent has not yet entered in host/person)

ii.     Pathogenesis

((in person,  begin with the entry of agent,  incubation,  early and late petrogenesis into host/person)

E. Prevention of disease (3  levels)

Prevention of disease, HECP, Pharmacy Notes, Pharmapedia, ThePharmapedia,
Prevention of disease (3  levels)

F. Emerging infectious diseases:

These are infections that have recently appeared within a population or those whose incidence or geographic range is rapidly increasing or threatens to increase in the near future or existing disease that has recently developed new clinical pattern, or developed resistance to existing therapy. Emerging infections can be caused by:

  • Previously undetected or unknown infectious agents
  • Known agents that have spread to new geographic locations or new populations
  • Previously known agents whose role in specific diseases has previously gone un-recognized.
  • Examples:
    • Severe acute respiratory syndrome (SARS) & MERS
    • H1N1 (bird flu/avian influenza): positive in India was reported on May 2009, from a passenger who traveled from the USA arriving at Hyderabad airport.
    • H5N1
    • chikungunya virus, Dengue, Zika virus, Nipah & Ebola virus, Meningococcal disease
  • Re-emerging infectious diseases(EIDs):
    • Re-emergence of agents whose incidence of disease had significantly declined in the past, but whose incidence of the disease has reappeared. This class of diseases is known as re-emerging infectious diseases.
      • Example: Chikungunya (2003 than re-emerge in 2007 after 3 years)​
  1. RNTCP:    Revised National Tuberculosis Control Programme (1997)
  2. DOTS:  directly observed treatment short course
  3. NTP:  national tuberculosis program (1962)
  4. NSP: national strategic program for tuberculosis elimination (2017-2025)  to control tuberculosis by 2025;  for strategic pillar-DTPB( detect,  treat, prevent &  build)
  5. NIKSHAY:  web based tuberculosis surveillance system
  6. NIKSHAY POSHAK YOJNA:     500 INR- incentive via DBT
  7. NLCP:  National leprosy Control Programme (1955)
  8. NLEP:  National leprosy eradication programme (1983)
  9. NVBDCP:  National Vector Borne Disease Control Programme
  10. IDSP:  integrated disease surveillance project
  11. NTCP:  National tobacco Control Programme
  12. NIDDCP:  National iodine deficiency disorder Control Programme (Iodine:  essential micronutrients,  Delhi requirement 100-150  microgram;  salt 15 PPM)
  13. NACP:  national AIDS control programme
  14. NVHCP:  National Viral hepatitis control program (28th JULY 2018 ON WORLD HEPATITIS DAY)

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